Modified Alginates for Islet Encapsulation and Diabetes Treatment

Exclusively Licensed

Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.

Researchers

Robert Langer / Arturo Vegas / Kaitlin Bratlie / Minglin Ma / Daniel Anderson

Departments: Office of the Institute Professors, Department of Chemical Engineering
Technology Areas: Biotechnology: Tissue Engineering / Chemicals & Materials: Catalysis & Synthesis, Polymers / Therapeutics: Cell Based Therapy

  • modified alginates for cell encapsulation and cell therapy
    United States of America | Granted | 11,337,930
  • modified alginates for cell encapsulation and cell therapy
    United States of America | Granted | 9,422,373
  • modified alginates for cell encapsulation and cell therapy
    Canada | Granted | 2,837,558
  • modified alginates for islet encapsulation and diabetes treatment
    European Patent Convention | Granted | 2,714,747
  • modified alginates for cell encapsulation and cell therapy
    United States of America | Granted | 10,285,949
  • modified alginates for cell encapsulation and cell therapy
    European Patent Convention | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    United States of America | Granted | 10,292,936
  • modified alginates for cell encapsulation and cell therapy
    United States of America | Granted | 10,842,753
  • modified alginates for cell encapsulation and cell therapy
    Hong Kong | Granted | 1,259,279
  • modified alginates for cell encapsulation and cell therapy
    European Patent Convention | Published application
  • modified alginates for cell encapsulation and cell therapy
    Austria | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Belgium | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Denmark | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    France | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Finland | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Greece | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Ireland | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Italy | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Netherlands | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Norway | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Spain | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Sweden | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Switzerland | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    Turkey | Granted | 3,354,665
  • modified alginates for cell encapsulation and cell therapy
    United Kingdom | Granted | 3,354,665
  • modified alginates for islet encapsulation and diabetes treatment
    Belgium | Granted | 2,714,747
  • modified alginates for islet encapsulation and diabetes treatment
    France | Granted | 2,714,747
  • modified alginates for islet encapsulation and diabetes treatment
    Germany | Granted | 2,714,747
  • modified alginates for islet encapsulation and diabetes treatment
    Ireland | Granted | 2,714,747
  • modified alginates for islet encapsulation and diabetes treatment
    Netherlands | Granted | 2,714,747
  • modified alginates for islet encapsulation and diabetes treatment
    Switzerland | Granted | 2,714,747
  • modified alginates for islet encapsulation and diabetes treatment
    United Kingdom | Granted | 2,714,747
  • modified alginates for cell encapsulation and cell therapy
    United States of America | Published application
  • modified alginates for cell encapsulation and cell therapy
    Germany | Granted | 3,354,665

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