Lipid/Polymer Nanoformulations with Alphavirus Replicon RNA
Exclusively Licensed
Invention type: Technology
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Case number: #17996H
Disclosed herein are lipid nanoparticles comprising 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000](DSPE-PEG2000), compositions including such lipid nanoparticles, and methods of treatment using such lipid nanoparticles and compositions.
Researchers
Darrell J Irvine
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Yuan Zhang
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Mariane Melo
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Tasuku Kitada
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Ron Weiss
Departments: David H Koch Institute for Integrative Cancer Res, Department of Biological Engineering
Technology Areas: Biotechnology: DNA & RNA Editing, Synthetic Biology / Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Nucleic Acids, Vaccines
Impact Areas: Healthy Living
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lipid nanoparticles and use thereof to deliver rna polynucleotides
United States of America | Granted | 11,026,894
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