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Synthetic Gene Circuits and Parts in Bacteroides

Technology / Case number: #17815
Timothy Lu / Mark Mimee / Christopher Voigt / Alex Tucker
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Systems, Methods, And Compositions For RNA-Guided RNA-Targeting CRISPR Effectors from Type III Systems

Technology / Case number: #23239
Omar Abudayyeh / Jonathan Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Biological State Machines

Technology / Case number: #18230
Timothy Lu / Nathaniel Roquet
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Platform for Continuous Directed Evolution in Human Cells

Technology / Case number: #19909
Matthew Shoulders / Louis Papa / Christopher Moore / Chet Berman / Samuel Hendel
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Crystal Structures of Human TorsinA and its Dystonia Mutant

Technology / Case number: #18394
Thomas Schwartz / Fatma Esra Demircioglu / Brian Sosa-Alvarado
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Concepts and Methods for Controlling Chemical Reaction Kinetics and Interaction Time in Large Systems

Technology / Case number: #18377
Kwanghun Chung / Evan Murray / Jae Cho
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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High-Throughput Native Context Mapping of the Regulatory Genome

Technology / Case number: #18012JQ
Nisha Rajagopal / Richard Sherwood / David Gifford
Technology Areas: Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Continuous Freeze-Drying of Pharmaceuticals and Biopharmaceuticals in Unit Doses

Technology / Case number: #19494J
Roberto Pisano / Capozzi Carlo / Bernhardt Trout
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Untranslated Region Engineering and Screening

Technology / Case number: #19123
Timothy Lu / Manolis Kellis / Jicong Cao / Eva Maria Novoa Pardo / Zhizhuo Zhang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Recombinase-Based Genetic Diversification Schemes

Technology / Case number: #18173
Timothy Lu / Sara Da Luz Areosa Cleto
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Multilayer Genetic Safety Kill Circuits Based on Single Cas9 Protein and Multiple Engineered gRNA in Mammalian Cells

Technology / Case number: #18163
Ron Weiss / Mohammad Reza Ebrahimkhani / Samira Kiani
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Electromechanical Lysis of Bacterial Pathogens using Ion Concentration Polarization

Technology / Case number: #19035
Minseok Kim / Jongyoon Han
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Compositions and Methods for Treating and Preventing Obesity

Technology / Case number: #18085J
Manolis Kellis / Melina Claussnitzer / Jan Korbel
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Open-Ended, Dicer-Cleavable Concatemeric siRNA Generated by Rolling Circle Transcription

Technology / Case number: #18076
Connie Wu / Kevin Shopsowitz / Paula Hammond
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

Delivery of Preassembled Double-Stranded Short Interference RNA-Argonaute Protein Complexes for Enhanced RNAi-Based Therapeutics

Technology / Case number: #19340
Jiahe Li / Yanpu He / Wade Wang / Paula Hammond
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
License

Discovery of Self-Labeling Miniproteins

Technology / Case number: #18742
Bradley Pentelute / Ethan Evans
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Uncharted Frontiers, Advanced Materials
License

METRAN - Software for 13C-metabolic Flux Analysis

Software / Case number: #12397
Technology Areas: Biotechnology / Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Connected World
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Structured DNA Conjugates

Technology / Case number: #18588
Mark Bathe / Sakul Ratanalert / Remi Veneziano / Tyson Shepherd / Hyungmin Jun
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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N/ASynergistic Tumor Treatment with IL-2, an Integrin-Binding-FC Fusion Protein, and a Cancer Vaccine

Technology / Case number: #18598HJ
Byron Kwan / Cary Opel / Kelly Moynihan / Darrell Irvine / Jennifer Cochran / Karl Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
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Highly Parallel Enzymatic DNA Synthesis Using Electrowetting Droplet Technology

Technology / Case number: #19620
Mark Bathe / Tyson Shepherd / James Banal / Joseph Berleant
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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