Enhanced Polypeptide Synthesis by UV Monitoring and Feedback Control

Exclusively Licensed

Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.

Researchers

Bradley L. Pentelute / Surin Mong / Alexander Mijalis / Dale Thomas / Mark Simon

Departments: Department of Chemistry
Technology Areas: Biotechnology: Biomanufacturing, Synthetic Biology / Diagnostics: Assays / Drug Discovery and Research Tools: Cell Interrogation, Genomics & Proteomics / Industrial Engineering & Automation: Manufacturing & Equipment / Sensing & Imaging: Chemical & Radiation Sensing, Optical Sensing
Impact Areas: Healthy Living

  • methods and systems for solid phase peptide synthesis
    United States of America | Granted | 11,584,776
  • methods and systems for solid phase peptide synthesis
    United States of America | Granted | 10,683,325
  • methods and systems for solid phase peptide synthesis
    Canada | Published application
  • methods and systems for solid phase peptide synthesis
    European Patent Convention | Published application
  • methods and systems for solid phase peptide synthesis
    United States of America | Granted | 12,043,646

License this technology

Interested in this technology? Connect with our experienced licensing team to initiate the process.

Sign up for technology updates

Sign up now to receive the latest updates on cutting-edge technologies and innovations.

More Technologies