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Microbial Production of 3,4-Dihydroxybutyrate (DHBA) and 3-Hydroxybutyrolactone (3-HBL) from Glucose

Technology / Case number: #14595
Kristala L Jones Prather / Himanshu Dhamankar / Collin Martin
Technology Areas: Chemicals & Materials / Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Protein Retrosplicing Enabled by a Double Ligation Reaction

Technology / Case number: #15368
Bradley L. Pentelute / Rocco Policarpo / Jingjing Ling / Amy Rabideau / Xiaoli Liao
Technology Areas: Computer Science / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Extended Transient Transfection by Repeated Delivery of RNA

Technology / Case number: #13415
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Engineering Microbes and Metabolic Pathways for the Production of Ethylene Glycol from Xylose, Glucose, Carbohydrates and Renewable Resources

Technology / Case number: #15064
Gregory Stephanopoulos / Jose Avalos / Marjan De Mey / Brian Pereira / Deepak Dugar
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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Brd4 as a Prognostic Indicator and Modulator of the Cell Response to DNA Damage

Technology / Case number: #15011
Michael Yaffe / Scott Floyd
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Generation of Specialized, High-Value Cells and Tissues from Human Induced Pluripotent Stem Cells by Recapitulating Early Embryogenesis Using Gata Factor-Induced Endoderm

Technology, Tangible Property / Case number: #16205
Ron Weiss / Mohammad Reza Ebrahimkhani / Patrick Guye
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Method for the Characterization and Differentiation of Material Surfaces Using Compound Responses of Mechanically Driven Cells

Technology / Case number: #17585J
Dick Yue / Xiaoying Zhu / Roland Bouffanais
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Cellular Surface Engineering via Multilayered Polymer Nanostructures

Technology / Case number: #12846
Robert Cohen / Albert Swiston / Darrell J Irvine / Michael F Rubner
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Ultrasonic Method for Measuring Concentrations of Particles, Cells and Islets in Suspension

Technology / Case number: #11886J
Clark Colton
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Tough, Thermoreversible Hydrogels from the Arrested Phase Separation of Elastin-Like Polypeptides: Simple, Injectable, Biocompatible Substrates for the Engineering of Load-Bearing Tissues

Technology / Case number: #17430
Bradley D. Olsen / Reginald Avery / Matthew Glassman
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Formulations for Stabilizing Lactobacillus and Bifidobacterium Strains

Technology / Case number: #25723J
Giovanni Traverso / Isaac Tucker / Kimberley Biggs / Mairead Heavey / Samantha Bozorgzadeh / Matt Murphy / Christina Karavasili
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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mRNA Subunit Vaccines for African Swine Fever

Technology / Case number: #25930
Jianzhu Chen / Fangfeng Yuan / Junru Cui
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Synthetic Nanotube Antibody for Selective Molecular Recognition

Technology / Case number: #14090
Michael S. Strano / Paul Barone
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Single-Walled Carbon Nano-Tube/Chitosan Hydrogel Array for the Label-Free, Optical Detection of Protein-Protein Interactions

Technology / Case number: #14201
Michael S. Strano / Nigel Reuel / Jin Ho Ahn / Paul Barone
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Genomic Editing with Site- Specific Retrotransposons

Technology / Case number: #25220
Omar Abudayyeh / Christopher Fell / Justin Lim / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Novel Recombinases and Target Sequences

Technology / Case number: #17809J
Ron Weiss / Gregory Batt / Xavier Duportet / Yinqing Li
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Covalently Functionalized Hydrogels on Oxygen Permeable Membranes for Stable, Scalable, and Xeno Free Growth of Undifferentiated Human Embryonic Stem Cells

Technology / Case number: #16162
Clark Colton / Amanda Diienno / Anna Coclite / Karen Gleason
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Extra Cellular Matrix Proteins and Cancer

Technology / Case number: #15501JHR
Richard Hynes / Kenneth Tanabe / Karl Clauser / Alexandra Naba / Steven Carr
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Cytosolically-Active Peroxidases as Reporters for Electron Microscopy

Technology / Case number: #15128
Alice Ting / Jeffrey Martell
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Methods for Cell Separation and Cytometry Based on Directed Cell Rolling on Patterned Substrates

Technology / Case number: #12899
Robert Langer / Suman Bose / Rohit N Karnik / Jeffrey Michael Karp / Daniel Anderson
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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