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Method for the Characterization and Differentiation of Material Surfaces Using Compound Responses of Mechanically Driven Cells

Technology / Case number: #17585J
Dick Yue / Xiaoying Zhu / Roland Bouffanais
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Method for High Efficiency in Vivo Gene Editing

Technology / Case number: #17117H
Tyler Jacks / Hao Yin / Joseph Dorkin / Wen Xue / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Cellular Surface Engineering via Multilayered Polymer Nanostructures

Technology / Case number: #12846
Robert Cohen / Albert Swiston / Darrell J Irvine / Michael F Rubner
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Ultrasonic Method for Measuring Concentrations of Particles, Cells and Islets in Suspension

Technology / Case number: #11886J
Clark Colton / Steven Africk
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Tough, Thermoreversible Hydrogels from the Arrested Phase Separation of Elastin-Like Polypeptides: Simple, Injectable, Biocompatible Substrates for the Engineering of Load-Bearing Tissues

Technology / Case number: #17430
Bradley D. Olsen / Reginald Avery / Matthew Glassman
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Genomic Editing with Site- Specific Retrotransposons

Technology / Case number: #25220
Omar Abudayyeh / Christopher Fell / Justin Lim / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Synthetic Nanotube Antibody for Selective Molecular Recognition

Technology / Case number: #14090
Michael S. Strano / Jingqing Zhang / Daniel Heller / Paul Barone / Jong Ho Kim
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Single-Walled Carbon Nano-Tube/Chitosan Hydrogel Array for the Label-Free, Optical Detection of Protein-Protein Interactions

Technology / Case number: #14201
Michael S. Strano / Nigel Reuel / Jin Ho Ahn / Paul Barone / Jong Ho Kim
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Novel Recombinases and Target Sequences

Technology / Case number: #17809J
Ron Weiss / Gregory Batt / Xavier Duportet / Yinqing Li
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Method for Modulating the Immune System Using Adjuvant-Loaded Nanoparticle-Bacteria Constructs

Technology / Case number: #16067J
Robert Langer / Georg Stary / Ulrich Von Andrian / Pamela Basto / Aleksandar Radovic-Moreno / Michael Starnbach / Omid Farokhzad
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Covalently Functionalized Hydrogels on Oxygen Permeable Membranes for Stable, Scalable, and Xeno Free Growth of Undifferentiated Human Embryonic Stem Cells

Technology / Case number: #16162
Clark Colton / Amanda Diienno / Anna Coclite / Karen Gleason
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Extra Cellular Matrix Proteins and Cancer

Technology / Case number: #15501JHR
Richard Hynes / Kenneth Tanabe / Karl Clauser / Alexandra Naba / Steven Carr
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Cytosolically-Active Peroxidases as Reporters for Electron Microscopy

Technology / Case number: #15128
Alice Ting / Jeffrey Martell
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Nanoparticle Delivery of Adjuvant-Method of Preparation and Uses Thereof

Technology / Case number: #13344J
Robert Langer / Elena Tonti / Jinjun Shi / Matteo Iannacone / Elliot Moseman / Ulrich Von Andrian / Pamela Basto / Frank Alexis / Omid Farokhzad
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Methods for Cell Separation and Cytometry Based on Directed Cell Rolling on Patterned Substrates

Technology / Case number: #12899
Robert Langer / Suman Bose / Ying Mei / Rohit N Karnik / Seungpyo Hong / Jeffrey Michael Karp / Daniel Anderson
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Thiol-yne Mediated Synthesis of Multi-Tailed Lipids for siRNA Delivery

Technology / Case number: #15846
Robert Langer / Akinleye Alabi / Kevin Love / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids

Technology / Case number: #16016J
Mo Movassaghi / Karen Morrison / Paul Hergenrother / Justin Kim / Nicolas Boyer
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Injectable Hydrogel and Uses Thereof

Technology / Case number: #16662J
Robert Langer / Eric Appel / Weiheng Wang / Omid Veiseh / Matthew Webber / Kun Xue / Benjamin Tang / Yizhou Dong / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Reversible Covalent Modification for Improving Protein Delivery

Technology / Case number: #16581HQ
Darrell J Irvine / Li Tang
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Self-Assembled (Poly-(L-Glutamic Acid-PEG-Drug)-PLGA Micelles for Multistage Nanoparticle Delivery System

Technology / Case number: #14877J
Moungi G Bawendi / Dai Fukumura / Cliff Wong / Rakesh K. Jain
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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