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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Daniel Anderson / Idris Raji / Jacob Witten / Allen Jiang / Luke Rhym
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Single-Cell RNA Sequencing Using Click-Chemistry

Technology / Case number: #20396
Phillip Sharp / D.B.Jay Mahat
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Ingestible Chemical Energy Harvesting System with Extended Lifetime

Technology / Case number: #23174
Giovanni Traverso / So-Yoon Yang / Jason Li
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Energy & Distribution / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Engineering a Swine Macro-Organ Colorectal Cancer Platform to Combat Transport-Induced Chemotherapy Resistance

Technology / Case number: #22864JQ
Robert Langer / Daniel Reker / Vance Soares / Yunhua Shi / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Closed-Loop Ingestible Robot for Radiation and Chemical Sensing

Technology / Case number: #22735
Giovanni Traverso / James Byrne / Hen Wei Huang
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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Ultra-high Efficiency Alcohol Engines Using Optimized Exhaust Heat Recovery

Technology / Case number: #15733K
Daniel Cohn / Leslie Bromberg
Technology Areas: Energy & Distribution / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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3D-Printed Field Emission Sources for Compact Systems

Technology / Case number: #21454J
Luis Fernando Velasquez-Garcia / Imperio Perales Martinez
Technology Areas: Chemicals & Materials / Electronics & Photonics / Industrial Engineering & Automation
Impact Areas: Advanced Materials
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Data Driven Material Discovery System

Technology / Case number: #21835J
Wojciech Matusik / Mina Konakovic Lukovic / Hanns-Hagen Goetzke / Bernhard Von Vacano / Klaus Stoll / Mina Lukovic / Wan Shou / Timothy Erps / Michael Foshey
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Industrial Engineering & Automation
Impact Areas: Advanced Materials
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Liquid Metal Printing

Technology / Case number: #21880J
Skylar Tibbits / Miya Nobuhiro / Masaki Otomori / Bjorn Sparrman / Schendy Kernizan / Jared Laucks
Technology Areas: Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Advanced Materials
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Pupil Engineering Method to Enhance the Signal of the Real-time non-invasive Particle Size Distribution Probe in Powders and During Mixing, Drying, Blending, and Milling Processes

Technology / Case number: #24521
George Barbastathis / Ajinkya Pandit / Zhen Guo / Qihang Zhang / Richard D Braatz / Allan S. Myerson
Technology Areas: Chemicals & Materials / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Advanced Materials
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Low-Temperature Synthesis of Two-Dimensional Materials

Technology / Case number: #24560
Jing Kong / Ji Hoon Park / Jiadi Zhu / Test User Qa260 / Tomas Palacios
Technology Areas: Chemicals & Materials / Electronics & Photonics / Energy & Distribution / Industrial Engineering & Automation
Impact Areas: Advanced Materials
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Nucleotide Depletion as Differentiation Therapy in the Treatment of Cancer

Technology / Case number: #21131J
Matthew Vander Heiden / Frances Diehl / David Sykes / Peggy Hsu
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Tissue Platform and Machine Learning Algorithm for Drug-Drug Transporter Interaction Discovery

Technology / Case number: #21883J
Robert Langer / Daniel Reker / Vance Soares / Yunhua Shi / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Derivation of Enteroendocrine Cells and Insulin Expressing Cells

Technology / Case number: #18445J
Robert Langer / Xiaolei Yin / Jeffrey Michael Karp
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Compositions Systems and Methods for Generating Inner Ear Hair Cells for Treatment of Hearing Loss

Technology / Case number: #17900J
Robert Langer / Nitin Joshi / Xiaolei Yin / Jeffrey Michael Karp
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Implantable Devices and Methods for Evaluation of Active Agents

Technology / Case number: #17867J
No Inventor / John Santini / Oliver Jonas / Jason Fuller / Robert Tepper
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Motorized and Balloon Dynamic Satiety Stimulator

Technology / Case number: #25050JQ
Giovanni Traverso / Neil Jia
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Learning Closed-Loop Control Policies for Manufacturing

Technology / Case number: #23744J
Wojciech Matusik / Michal Piovarèi / Bernd Bickel / Szymon Rusinkiewicz / Michael Foshey / Piotr Didyk
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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A Two-Phase Gripper to Reorient and Grasp

Technology / Case number: #18047KJ
Matthew Mason / Alberto Rodriguez / Nikhil Chavan Dafle
Technology Areas: Industrial Engineering & Automation
Impact Areas: Connected World
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Attention Buffer

Technology / Case number: #18153QJ
Bryan Reimer / Bobbie Seppelt / Linda Angell / Joonbum Lee / Bruce L Mehler / Joseph Coughlin
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Industrial Engineering & Automation
Impact Areas: Uncharted Frontiers
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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