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Machine Learning-Guided Discovery of Nanoparticle Formulations Maximizing mRNA Transfection

Technology / Case number: #25890J
Giovanni Traverso / Taksim Ahmed / Hao Song / Xisha Huang / Simon Qu / Deepak Subramanian / Jonathan Woo / Alvin Chan / Joshua Bernstock / Ameya Kirtane
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Computational Method for Identifying the Biophysical Interactions that Determine Human T Cell Specificity from Structural Data and Primary Amino Acid Sequences

Technology / Case number: #26026J
Xingcheng Lin / Jason George / Ailun Wang / José Onuchic / Herbert Levine
Technology Areas: Computer Science / Therapeutics
Impact Areas: Healthy Living
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Modular Continuous Lyophilizer

Technology / Case number: #26102J
Alexander Slocum / Joshua Dittrich / Rohan Kadambi / Steven Burcat / Roberto Pisano / Richard D Braatz / Bernhardt Trout
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Connected World
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Reactive Extraction of Metals

Technology / Case number: #26160
Yet-Ming Chiang
Technology Areas: Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Connected World
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Mucin-Inspired Glycopolypeptides for Managing Microbial Infections

Technology / Case number: #26189J
Katharina Ribbeck / Jessica Kramer / Michaela Gold / Kelsey Wheeler
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Women's Health
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Conservative Signal Processing Architectures for Asynchronous, Distributed Optimization:

Technology / Case number: #17185
Tom Baran / Tarek Lahlou
Technology Areas: Computer Science / Industrial Engineering & Automation
Impact Areas: Connected World
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CD80 is a Biomarker of p53 Activity and a Target for Cancer Therapy

Technology / Case number: #15386H
Tyler Jacks / Leah Schmidt / David Feldser
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Polyamine-Fatty Acid Derived Lipidoids for Drug Delivery

Technology / Case number: #16367
Daniel Anderson / Rebecca McClellan / Owen Fenton / Joseph Dorkin
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Methods for Growth of Carbon Nanostructures on Carbon Fibers

Technology / Case number: #15144
Brian L Wardle / Richard Li / Stephen Steiner
Technology Areas: Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Advanced Materials
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Valency Controlled Quantum Dots with Tunable Number of Biotin Binding Sites

Technology / Case number: #12606B
Moungi G Bawendi / Wenhao Liu / Mark Howarth / Alice Ting
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living
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Methods and Compositions for Protein Labeling Using Lipoic Acid Ligases

Technology / Case number: #12773
Alice Ting / Marta Fernandez Suarez / Yoon-Aa Choi / Hemanta Baruah
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Self-Assembling Peptides Incorporating Modifications and Methods of Use Thereof

Technology / Case number: #13846XE
Shuguang Zhang / Yoshiyuki Kumada
Technology Areas: Biomaterials & Bioelectronics / Therapeutics
Impact Areas: Healthy Living
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Low Energy Magnetic Domain Wall Logic Device

Technology / Case number: #14967
Caroline Ross / Jean Anne Currivan Incorvia / Marc Baldo
Technology Areas: Industrial Engineering & Automation
Impact Areas: Connected World
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Temperature Sensor and Array

Technology / Case number: #17359L
Carl Bozler / Douglas Bryant / Shaun Berry / Jeremy Muldavin / Robert Reich / Harry Clark
Technology Areas: Communication Systems / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Healthy Living
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A Mitochondria Targeting Platinum(IV) Complex with Dual Cell Killing Modes

Technology / Case number: #13271
Stephen J Lippard / Shanta Dhar
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Hitless Tuning and Switching of Optical Resonator Amplitude and Phase Responses

Technology / Case number: #12617
Michael Watts
Technology Areas: Communication Systems / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Connected World
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Research Environment for Supervisory Control of Unmanned Vehicles (RESCHU)

Technology / Case number: #13467
Mary Cummings / Yale Song / Carl Nehme
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Industrial Engineering & Automation
Impact Areas: Connected World
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Formulation of Polymeric Particles for Prostate Cancer Targeting

Technology / Case number: #12162J
Robert Langer / Stephen Zale / Benjamin Teply / Jianjun Cheng / Omid Farokhzad
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Pulse-Modulated Feedback Control to Overcome High Non-Linearities

Technology / Case number: #14017
Neville Hogan / Yun Seong Song
Technology Areas: Industrial Engineering & Automation
Impact Areas: Connected World
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Antigenically Intact Hemagglutinin in Circulating Avian and Swine Influenza Viruses and Potential for H3N2 Pandemic

Technology / Case number: #16225
Rahul Raman / Kannan Tharakaraman / Ram Sasisekharan
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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