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Engineering a Swine Macro-Organ Colorectal Cancer Platform to Combat Transport-Induced Chemotherapy Resistance

Technology / Case number: #22864JQ
Carlo Giovanni Traverso / Yunhua Shi / Vance Soares / Daniel Reker / Robert Langer
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Enhancement of Lignocellulosic Fermentation in S. Cerevisiae by Combined Genetic Modulations and Media Supplementation

Technology / Case number: #21982WJ
Felix Lam / Gregory Stephanopoulos / Gerald Fink
Technology Areas: Biotechnology / Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Sustainable Future
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Devices, Methods and Systems for Recycling Combustion Ash

Technology / Case number: #22655J
Elsa Olivetti / Venkat Viswanathan / Leah Ellis / Sophie Coppieters T Wallant / Sonia Zhang / Michael Wang / Yet-Ming Chiang
Technology Areas: Environmental Engineering
Impact Areas: Sustainable Future
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Electrochemical Direct Air Capture of CO2 Using Neutral Red as Reversible Redox-Active Material

Technology / Case number: #24363
Trevor Hatton / Hyowon Seo
Technology Areas: Environmental Engineering
Impact Areas: Climate Stabilization
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Catalytic Oxidation Reactors for the Removal of Low-Level Methane in Air

Technology / Case number: #24434
Desiree Plata / Asegun Henry / Mehdi Pishahang / Qingzi Zhu / Rebecca Brenneis / Anastasios Hart
Technology Areas: Chemicals & Materials / Environmental Engineering
Impact Areas: Climate Stabilization, Advanced Materials
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Direct-Drive (Batteryless) Electrodialysis Separation using Flow-Commanded Current Control

Technology / Case number: #24538
Amos Winter / Shane Pratt / Jonathan Bessette
Technology Areas: Environmental Engineering
Impact Areas: Sustainable Future
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Controller for Management of Optimal Schedules, used with Renewable-Energy Powered Irrigation Systems

Technology / Case number: #24578
Amos Winter / Georgia Van de Zande / Fiona Grant / Shane Pratt / Carolyn Sheline / Simone Gelmini
Technology Areas: Agriculture & Food / Environmental Engineering / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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Methods for Producing High-Level Squalene in Yarrowia Lipolytica

Technology / Case number: #24579
Yongshuo Ma / Gregory Stephanopoulos
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Photoelectrochemical Capture of Acid Gases (Solar-Driven Carbon Dioxide Capture)

Technology / Case number: #24581
Trevor Hatton / Alexandra Victoria Tavasoli / Vittoria Bolongaro / Kyle Diederichsen
Technology Areas: Energy & Distribution / Environmental Engineering
Impact Areas: Sustainable Future
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Electrochemical CO2 Conversion Architecture

Technology / Case number: #24598
Simon Rufer / Kripa Varanasi
Technology Areas: Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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Cellular Backpacks for Drug Delivery Across the Blood-Brain Barrier

Technology / Case number: #18547J
Roberta Polak / Elena Batrakova / Matthew Haney / Yuling Zhao / Natalya Klyachko / Michael Rubner / Robert Cohen
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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In-Pipe Leak Detection System

Technology, Tangible Property / Case number: #19034JC
Rached Ben-Mansour / You Wu / Kristina Kim / Michael Henry / Kamal Youcef-Toumi
Technology Areas: Agriculture & Food / Environmental Engineering / Sensing & Imaging
Impact Areas: Sustainable Future
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Nucleotide Depletion as Differentiation Therapy in the Treatment of Cancer

Technology / Case number: #21131J
Matthew Vander Heiden / Peggy Hsu / David Sykes / Frances Diehl
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Tissue Platform and Machine Learning Algorithm for Drug-Drug Transporter Interaction Discovery

Technology / Case number: #21883J
Carlo Giovanni Traverso / Yunhua Shi / Vance Soares / Daniel Reker / Robert Langer
Technology Areas: Biomaterials & Bioelectronics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Polymers for Messenger RNA Delivery to the Lung

Technology / Case number: #19314
Kevin Kauffman / James Kaczmarek / Asha Patel / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure-Guided Chemical Modification of Guide RNA and its Applications

Technology / Case number: #19175V
Hao Yin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Thin-film Nanocomposite Membranes for Separating Ions and Uncharged Species in Water

Technology / Case number: #24335
Zachary Smith / Gang Han
Technology Areas: Chemicals & Materials / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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Pore Creation Methods in Monolayer Graphene for Membrane Applications

Technology / Case number: #18915J
Jing Kong / Rohit Karnik / Tahar Laoui / Piran Kidambi / Ahmed Ibrahim / Sui Zhang
Technology Areas: Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Advanced Materials
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Ionizable Lipids for Messenger RNA Delivery

Technology, Tangible Property / Case number: #24861
Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Brice Curtin / Jasmin Kruell / Catherine Henry / Sebastian Pomplun / Christina Woo / Chia-fu Chang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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