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Cellular Backpacks for Drug Delivery Across the Blood-Brain Barrier

Technology / Case number: #18547J
Roberta Polak / Elena Batrakova / Matthew Haney / Yuling Zhao / Natalya Klyachko / Michael Rubner / Robert Cohen
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Nucleotide Depletion as Differentiation Therapy in the Treatment of Cancer

Technology / Case number: #21131J
Matthew Vander Heiden / Peggy Hsu / David Sykes / Frances Diehl
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Tissue Platform and Machine Learning Algorithm for Drug-Drug Transporter Interaction Discovery

Technology / Case number: #21883J
Carlo Giovanni Traverso / Yunhua Shi / Vance Soares / Daniel Reker / Robert Langer
Technology Areas: Biomaterials & Bioelectronics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Polymers for Messenger RNA Delivery to the Lung

Technology / Case number: #19314
Kevin Kauffman / James Kaczmarek / Asha Patel / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure-Guided Chemical Modification of Guide RNA and its Applications

Technology / Case number: #19175V
Hao Yin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Ionizable Lipids for Messenger RNA Delivery

Technology, Tangible Property / Case number: #24861
Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Brice Curtin / Jasmin Kruell / Catherine Henry / Sebastian Pomplun / Christina Woo / Chia-fu Chang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Single-shot 16-fold Expansion Microscopy (16ExM)

Technology / Case number: #24859MH
Edward Boyden / Laura Kiessling / Tay Won Shin / Shiwei Wang / Yixi Liu / Harley Yoder
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Clockwise Learning Task

Technology / Case number: #25128M
Georgios Papageorgiou / Ann Graybiel
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Engineered Synthetic IRES with Improved and Robust Translation in Circular RNA

Technology / Case number: #25300YJ
James Collins / Katherine Ilia / Shiva Razavi / Kehan Zhang / Xiaoyu Chen / Makoto Lalwani / Yu Li / Nayoung Kim
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Reconstituted Lipoprotein Particles to Rescue Lipid Defects in the Alzheimer's Brain

Technology / Case number: #25445P
Li-Huei Tsai / Rebecca Pinals
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Ultra-High Resolution Mapping of 3D Genome Structure using Region Capture Micro-C

Technology / Case number: #24967
Anders Sejr Hansen / Viraat Goel / Miles Huseyin
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Optimized Alum-Anchored HIV Env Immunogens

Technology / Case number: #24972HJ
Kristen Rodrigues / Christopher Cottrell / Jon Steichen / William Schief / Darrell Irvine
Technology Areas: Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High Coherence, Small Footprint Superconducting Qubit made by Stacking up Atomically Thin Crystals

Technology / Case number: #21842
William Oliver / Simon Gustavsson / I-Jan Wang
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Electronics & Photonics
Impact Areas: Uncharted Frontiers, Advanced Materials
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Majorana Pair based Qubits for Fault Tolerant Quantum Computing Architecture using Superconducting Gold Surface States

Technology / Case number: #21329
Peng Wei / Sujit Manna / Jagadeesh Moodera / Patrick Lee
Technology Areas: Chemicals & Materials / Computer Science
Impact Areas: Advanced Materials
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Architecture for Quantum Optical Repeaters and Neural Networks

Technology / Case number: #21162
Dirk Englund / Gregory Steinbrecher / Jacques Johannes Carolan
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Electronics & Photonics
Impact Areas: Uncharted Frontiers, Advanced Materials
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A Molecular Clock

Technology / Case number: #20207
Ruonan Han / Cheng Wang
Technology Areas: Chemicals & Materials / Communication Systems / Computer Science
Impact Areas: Connected World, Advanced Materials
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Biodegradable Lipids and Formulations for Intramuscular, In Vitro, and Ex Vivo Transfection of mRNA

Technology / Case number: #23969J
Arnab Rudra / Akash Gupta / Kaelan Reed / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Diagnostic and Treatment Prediction Toolkit for Bipolar Disorder based on Polymorphisms in CPG2 Regulatory Domains

Technology / Case number: #23591P
Baovi Vo / Elly Nedivi
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Fluorescence-based detection of protein aggregation and fiber optic-based benchtop instrument

Technology / Case number: #21556
Michael Strano / Daichi Kozawa / Xun Gong / Daniel Salem / Sooyeon Cho / Freddy Nguyen
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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