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Novel Cancer Therapeutics through Brain Stimulation

Technology / Case number: #25655TE
Deblina Sarkar / Ishaq Khan / Ray Lee / Monochura Saha
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Estimating Contractile Reserve using a Mechanical Circulatory Support Device

Technology / Case number: #25817J
Elazer Edelman / Steven Keller / Ahmad El Katerji / Jerald Curran
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Biomarkers Derived from Neurophysiological Computational Modeling

Technology / Case number: #18088L
Satrajit Ghosh / Jeffrey Palmer / Christopher Smalt / Brian Helfer / Daryush Mehta / James Williamson / Gregory Ciccarelli / Joseph Perricone / Thomas Quatieri
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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System and Method to Predict Exertional Heat Stroke from Torso-Worn Sensor

Technology / Case number: #21970LJ
Jeffrey Palmer / Brian Telfer / James Williamson / Lara Weed / Mark Buller / Rebecca Fellin / Joseph Seay
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Micro-Invasive Neural System for Delivering Antiseizure Medications to the Epileptic Focus for the Treatment of Refractory Epilepsy

Technology / Case number: #25721J
Michael Cima / Max Cotler / Hannah Jackson / Cameron Metcalf / Karen Wilcox / Peter West
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Single-Step Insertion into Repeated Regions for Efficient Multi-Locus Assortment and Daisyfield Drive

Technology / Case number: #19136TJE
Kevin Esvelt / Jianghong Min / Charleston Noble
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Novel Short Tandem Repeats (STRs) Analysis Methods

Technology / Case number: #18500L
Edward Wack / Anna Shcherbina / Brian Helfer / Darrell Ricke / Joseph Isaacson / Adam Michaleas / Philip Fremont-Smith / James Watkins / James Harper / Martha Petrovick / Eric Schwoebel
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Synthetic Hydrogels for Stem Cell Propagation and Organogenesis

Technology / Case number: #20047
Linda Griffith
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Optimized Opsin Trafficking with Fluorescence-Dead Protein Fusions

Technology / Case number: #18783TE
Edward Boyden / Kiryl Piatkevich / Aimei Yang / Demian Park
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Dynamic Single-Cell Fragility Test that Assesses Red Blood Cell Membrane Integrity with Applications to Stored Blood

Technology / Case number: #25732
Fang Kong / Subra Suresh / Ming Dao
Technology Areas: Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Computationally Engineering Integrase Variants with Improved Activity

Technology / Case number: #25676
Omar Abudayyeh / Jonathan Gootenberg / Kaiyi Jiang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Methods for the Treatment of Trinucleotide Repeat Expansion Disorders Associated with FAN1 activity via Targeting of FAN1 Splice Site Inhibitory Sequences

Technology / Case number: #24829
Christopher Ng / David Housman
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Method for Zero Phase-Lag Real-Time Computation of Hilbert Transform and Analytic Signal

Technology / Case number: #18073TEJ
Edward Boyden / Nir Grossman / David Wang
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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Closed-Loop Noninvasive Brain Stimulation with Simultaneous Imaging to Control Cerebrospinal Fluid Flow in Humans

Technology / Case number: #25482
Laura Lewis / Joshua Levitt
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Computer Science / Sensing & Imaging
Impact Areas: Healthy Living
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Methods for Improving Cross-Ancestry Transferability in Predicting Polygenic Phenotypes from Genetic Variation

Technology / Case number: #24858
Manolis Kellis / Yosuke Tanigawa
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Ingestible Electronics Integrated with Flexible Measurement Electrodes for Gastrointestinal Bioelectric Sensing

Technology / Case number: #23241
Carlo Giovanni Traverso / Robert Langer / Siheng You / So-Yoon Yang / Adam Gierlach / George Selsing
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Computer Science
Impact Areas: Healthy Living, Advanced Materials
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RNAI-Based Method of Screening and Characterizing Drug Combinations

Technology / Case number: #19756
Michael Hemann / Justin Pritchard / Douglas Lauffenburger
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Bioelectronic Devices to Support Transplanted Cells in Vivo for Encapsulated Cell Therapies

Technology / Case number: #23269J
Suman Bose / Robert Langer / Siddharth Krishnan / Matthew Bochenek / Nima Khatib / Daniel Anderson
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Energy & Distribution / Therapeutics
Impact Areas: Healthy Living
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Multisensory Gamma Stimulation Promotes Glymphatic Clearance of Amyloid

Technology / Case number: #25696PH
Li-Huei Tsai / Edward Boyden / Ping-Chieh Pao / Cheng-Yi Yang / Mitchell Murdock
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Genotype-Directed Local Delivery of Targeted Therapeutics at the Tumor Margin

Technology / Case number: #19863J
Carlo Giovanni Traverso / Ameya Kirtane / Daniel Cahill / Ganesh Shankar / Robert Langer
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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