Biomarkers Derived from Neurophysiological Computational Modeling

In a system and method for assessing the condition of a subject, control parameters are derived from a neurophysiological computational model that operates on features extracted from a speech signal. The control parameters are used as biomarkers (indicators) of the subject's condition. Speech related features are compared with model predicted speech features, and the error signal is used to update control parameters within the neurophysiological computational model. The updated control parameters are processed in a comparison with parameters associated with the disorder in a library.

Researchers

Thomas Quatieri / Joseph Perricone / Gregory Ciccarelli / Jim Williamson / Daryush Mehta / Brian Helfer / Christopher Smalt / Jeffrey Palmer / Satrajit Ghosh

Departments: Lincoln Laboratory, Office of Religious, Spiritual, and Ethical Life, McGovern Institute for Brain Research
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics: Health Monitoring / Biotechnology: Biomedical Devices & Systems, Sensors & Monitoring
Impact Areas: Healthy Living

  • assessing disorders through speech and a computational model
    United States of America | Granted | 10,127,929

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