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Method for High Efficiency in Vivo Gene Editing

Technology / Case number: #17117H
Tyler Jacks / Hao Yin / Joseph Dorkin / Wen Xue / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Modular MicroRNA Expression from Self-Replicating RNA (Replicons)

Technology / Case number: #25464
Ron Weiss / Tea Crnkovic
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Production of Stable Non-Polyadenylated RNAs

Technology / Case number: #15860
Phillip Sharp / Jeremy Wilusz
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living
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Human Microbiome Clostridia-Derived Biosynthetic Enzymes/Pathways for the Biological Production of Natural and Non-Natural Fatty Acylated Compounds

Technology / Case number: #20961
Christopher Voigt / Fang-Yuan Chang
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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In Vitro and in Vivo Delivery of Complex Genetic Circuits up to 33kb Using Engineered HSV-1

Technology / Case number: #20746
Ron Weiss / Ross Jones / Jin Huh / Maria Hottelet Foley
Technology Areas: Diagnostics / Drug Delivery
Impact Areas: Healthy Living
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Cellular Backpacks for Drug Delivery Across the Blood-Brain Barrier

Technology / Case number: #18547J
Robert Cohen / Natalya Klyachko / Yuling Zhao / Matthew Haney / Elena Batrakova / Roberta Polak / Michael F Rubner
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Anti-Zika Virus Antibodies

Technology / Case number: #18525J
Ram Sasisekharan / Subhash Vasudevan / Satoru Watanabe / Kuan Chan / Eng Ooi / Kannan Tharakaraman
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
License

Spatially Localized Gene Delivery of Adeno-Associated Viruses

Technology / Case number: #25055
Polina Anikeeva / Keisuke Nagao
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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MicroRNA-based Logic Gates that Do Not Use Exogenous Proteins

Technology / Case number: #21334
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Carbon Nanoparticles for use as a Vehicle to Target and Treat Macrophages, and Macrophage RNF41 as a Molecule Essential to Switch Macrophage Phenotype

Technology / Case number: #22023
Elazer R Edelman / Pedro Melgar Lesmes
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Darrell J Irvine / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

M13 Phage based Gene Therapy Platform (Chapter 4 of Thesis Work)

Technology / Case number: #23296
Angela Belcher / Uyanga Tsedev
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Preferential Crystallization of fullrAAVs in a Hanging Drop Crystallizer as an Alternative Method for Downstream Purification of rAAV-based Gene Therapies

Technology / Case number: #24870
Anthony Sinskey / Vivekananda Bal / Moo Sun Hong / Stacy Springs / Richard D Braatz / Paul Barone
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Control Replication and Transcription of Self-Replicating RNA in Responses to Small Molecule TMP

Technology / Case number: #22331H
Darrell J Irvine / Parisa Yousefpour / Jan Lonzaric / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Fusion Capsid Therapy for COVID-19 and Applies to Other Viruses: Universal "Dominant" Antiviral to Prevent Virus Evolution and Future Pandemics (DNA/RNA/Protein)

Technology, Tangible Property / Case number: #22801MH
Robert Langer / Bowen Li / Yong Qian / Alexi Choueiri / Edward Stuart Boyden / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Multi-Targeted, Tunable, Sustained Delivery of Drugs and Other Payloads to Charged Avascular Tissues

Technology / Case number: #21303
Alan Grodzinsky / Yamini Krishnan
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Targeting Dendritic Cell Lectins with Glycosylated Particles Containing TLR Ligands Facilitates Efficient Immune Responses

Technology / Case number: #24570J
Laura L Kiessling / Robert Hincapie / Mohammad Murshid Alam / M.G. Finn / Valerie Lensch
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Engineered Phagemids for Non-Lytic, Targeted Antibacterial Technologies

Technology / Case number: #18186HJY
James Collins / Michael Lobritz / Prerna Bhargava / Russell-John Krom
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

filtered: 18 results

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