In Vitro and in Vivo Delivery of Complex Genetic Circuits up to 33kb Using Engineered HSV-1

Provided herein are engineered HSV-1 vectors comprising a modified HSV-1 genome. The engineered HSV-1 vectors can be used to deliver genetic circuits (e.g., up to 100 kb) to cells in vitro or in vivo. Methods of treating or diagnosing a disease (e.g., cancer) using the engineered HSV-1 vectors described herein are also provided.

Researchers

Ron Weiss / Maria Hottelet Foley / Jin Huh / Ross Jones

Departments: Department of Biological Engineering
Technology Areas: Diagnostics: Assays / Drug Delivery: Vectors & Virus like Particles
Impact Areas: Healthy Living

  • engineered herpes simplex virus-1 (hsv-1) vectors and uses thereof
    United States of America | Published application | 0
  • engineered herpes simplex virus-1 (hsv-1) vectors and uses thereof
    China | Published application
  • engineered herpes simplex virus-1 (hsv-1) vectors and uses thereof
    European Patent Convention | Published application
  • engineered herpes simplex virus-1 (hsv-1) vectors and uses thereof
    Japan | Published application
  • engineered herpes simplex virus-1 (hsv-1) vectors and uses thereof
    Hong Kong | Published application

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