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Injectable, Thermogelling, Prolonged-Release Hydrogel Formulations for CPG-ODNs

Technology / Case number: #26051J
Robert Langer / Stephen Linderman / Eric Wehrenberg-Klee / Jan-Georg Rosenboom / Avik Som / Ameya Kirtane / Giovanni Traverso
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Self-Righting Systems, Methods, and Related Components

Technology / Case number: #20706JQ
Robert Langer / Ester Caffarel Salvador / Niclas Roxhed / Minsoo Khang / Alex Abramson / Taylor Bensel / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Triggerable Shape Memory Gastric Devices for Drug Delivery

Technology / Case number: #17860
Robert Langer / Yida Zhao / Shiyi Zhang / Giovanni Traverso
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Method for Controlling mRNA-Loaded Lipid Nanoparticles through Post-Injection and Buffer Control

Technology / Case number: #26460
Allan S. Myerson / Cedric Devos / Aniket Pradip Udepurkar / Peter Sagmeister / Richard D Braatz
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Self-Assembling Drug Delivery Devices For Gastrointestinal Retention

Technology / Case number: #17002J
Robert Langer / Jiaqi Lin / Stacy Mo / Angela Diciccio / William Gates / Boris Nikolic / Phillip Eckhoff / Dean Glettig / Shiyi Zhang / Andrew Bellinger / Lowell Wood / Giovanni Traverso
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Delivery Systems for Anti-Retroviral Drugs

Technology / Case number: #18813J
Robert Langer / Omar Abouzid / Ameya Kirtane / Mousa Jafari / Tyler Grant / Stacy Mo / Angela Diciccio / Dean Glettig / Shiyi Zhang / Andrew Bellinger / Giovanni Traverso
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Devices for Needless Drug Delivery in the GI tract

Technology / Case number: #21911QJ
Robert Langer / Adam Jun Bohr / Aghiad Ghazal / Drago Sticker / Cody Cleveland / Torben Sebastia Last / Yi Lu / Graham Arrick / Declan Gwynne / Sean You / Jacob Wainer / Niclas Roxhed / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Precision Administration of Ultra-Loaded Injectable Nanocarriers (PAULINA)

Technology / Case number: #26169J
Giovanni Traverso / Cooper Konz / Yogesh Deshpande / Nabil Shalabi / Will Tritschler / SeungHo Lee / Jason Li
Technology Areas: Drug Delivery
Impact Areas: Healthy Living
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Methods, Procedures, and Material Compositions to Formulate Thermally Stable Solid-State Lipid Nanoparticles via Drying at Ambient Conditions

Technology / Case number: #26177
Robert Langer / Amy Lee / Khanh Tran / Jinbi Tian / Mina Konakovic Lukovic / Ana Jaklenec
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Poly(-amino ester) Microparticles for Micronutrient Fortification

Technology / Case number: #22992
Robert Langer / Linzixuan Rhoda Zhang / Ruiqing Xiao / Ana Jaklenec
Technology Areas: Agriculture & Food / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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AO mRNA-LNP Stabilization

Technology / Case number: #26266
Robert Langer / Tina Huang / Jooli Han / Linzixuan Rhoda Zhang / Ana Jaklenec
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Lipid-Polymer Microparticles (mLPM) For Thermostable, Pulsatile mRNA-LNP Vaccines

Technology / Case number: #26154
Robert Langer / Yuting Huang / Linzixuan Rhoda Zhang / Ana Jaklenec
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Branched Poly(-amino esters) for the Delivery of Nucleic Acids

Technology / Case number: #20333JQ
Robert Langer / Gary Liu / James Byrne / Netra Kamat / Hyunjoon Kim / Daniel Reker / Grace Junyue Zhong / Ameya Kirtane / Yunhua Shi / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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A Mechanical Underwater Soft Adhesion System for Kinetic Biosensing and Intelligent Targeted Drug Delivery

Technology / Case number: #26028J
Giovanni Traverso / Yubin Cai / Troy Ziliang Kang / Ming Zhao / Ameya Kirtane
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Lipid Compositions and Methods

Technology / Case number: #25115J
Daniel Anderson / Dennis Shi / Theresa Raimondo / Sho Toyonaga
Technology Areas: Drug Delivery
Impact Areas: Healthy Living
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Synergisms between Small Molecule Boosters and LNP Formulations Uncovered using High Throughput Screening and Machine Learning

Technology / Case number: #26199J
Giovanni Traverso / Deepak Subramanian / Rajib Dey / Ameya Kirtane
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Biodegradable Lipid-Like Materials for Applications in siRNA Delivery

Technology / Case number: #15420
Robert Langer / Joseph Dorkin / Yunlong Zhang / Arturo Vegas / Kathryn Whitehead / Daniel Anderson
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Compositions and Methods to Deliver RNA to Extracellular Matrix Producing Cells

Technology / Case number: #25390J
Daniel Anderson / Dennis Shi / Theresa Raimondo / Sho Toyonaga
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Self- Regulated Peptide Hydrogel for Closed Loop Insulin Delivery

Technology / Case number: #15056J
Robert Langer / Alex Aimetti / Zhen Gu / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
License

Ultrasound-Mediated Gastrointestinal Drug Delivery

Technology / Case number: #17807JQ
Robert Langer / Carl Schoellhammer / Baris Polat / Giovanni Traverso / Avraham Schroeder / William Brugge / Daniel Blankschtein
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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