1,2-Aminoalcohol Lipidoids (II)

Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

Researchers

Robert Langer / Kathryn Whitehead / Christopher Levins / Kevin Love / Kerry Mahon / Daniel Anderson

Departments: Office of the Institute Professors, Department of Chemical Engineering
Technology Areas: Chemicals & Materials: Catalysis & Synthesis / Drug Delivery: Microparticles & Nanoparticles
Impact Areas: Healthy Living

  • aminoalcohol lipidoids and uses thereof
    United States of America | Granted | 11,414,393
  • aminoalcohol lipidoids and uses thereof
    United States of America | Granted | 8,969,353
  • no longer use - forrester id to use: 125878
    Mexico | Issued | 328,428
  • aminoalcohol lipidoids and uses therefore
    United States of America | Granted | 10,189,802
  • aminoalcohol lipidoids and uses thereof
    Austria | Issued | 906,128
  • aminoalcohol lipidoids and uses thereof
    Belgium | Issued | 2,365,962
  • aminoalcohol lipidoids and uses thereof
    Bulgaria | Issued | 2,365,962
  • aminoalcohol lipidoids and uses thereof
    Finland | Issued | 0
  • aminoalcohol lipidoids and uses thereof
    Ireland | Issued | 2,365,962
  • aminoalcohol lipidoids and uses thereof
    Iceland | Issued | 0
  • aminoalcohol lipidoids and uses thereof
    Luxembourg | Issued | 0
  • aminoalcohol lipidoids and uses thereof
    Monaco | Issued | 0
  • aminoalcohol lipidoids and uses thereof
    Netherlands | Issued | 0
  • aminoalcohol lipidoids and uses thereof
    United States of America | Granted | 10,844,028

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