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Genotype-Directed Local Delivery of Targeted Therapeutics at the Tumor Margin

Technology / Case number: #19863J
Carlo Giovanni Traverso / Ameya Kirtane / Daniel Cahill / Ganesh Shankar / Robert Langer
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Formulated, Biodegradable Polymeric Nanoparticles for Nucleic Acid Delivery to Non-Liver Targets

Technology / Case number: #19802
Kevin Kauffman / James Kaczmarek / Asha Patel / Luke Rhym / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Luke Rhym / Allen Jiang / Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Bioinspired Design of Self-Adjuvanted C3d-Fusion SARS-CoV-2 mRNA Vaccines

Technology / Case number: #23326
Robert Langer / Bowen Li / Allen Jiang / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Gene Delivery Carrier

Technology / Case number: #19091J
Umberto Palmiero / James Kaczmarek / Davide Moscatelli / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Advanced Materials
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Derivation of Enteroendocrine Cells and Insulin Expressing Cells

Technology / Case number: #18445J
Jeffrey Karp / Xiaolei Yin / Robert Langer
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Brice Curtin / Jasmin Kruell / Catherine Henry / Sebastian Pomplun / Christina Woo / Chia-fu Chang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Small Molecule Inhibitors of Interleukin-4

Technology / Case number: #22186
Angela Koehler / Arturo Vegas / Shelby Doyle / Becky Leifer / Sean Quinnell / Stephen Nestor / Kelly Tan / Luke Ceo / Daniel Sheehy
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Pooled Screening Identifies Genomic Features (Biomarkers) Modulating Nanoparticle-Cell Interactions

Technology / Case number: #22785J
Angela Koehler / Natalie Boehnke / Joelle Straehla / Paula Hammond
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Spatially Localized Gene Delivery of Adeno-Associated Viruses

Technology / Case number: #25055
Polina Anikeeva / Keisuke Nagao
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Combinations of Anesthetics as Therapies for Treatment-Resistant Depression

Technology / Case number: #25342P
Emery Brown / Sirma Orguc / Ohyoon Kwon / Bryan Tseng / Macauley Breault / Gloria Kang
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Method of Enhanced Clearance of Uremic Toxins in Hemodialysis using Nanoporous Membranes

Technology / Case number: #21853
Rohit Karnik / Aaron Persad / Chun Man Chow / Chi Cheng
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Selective Valorization of Biomass Sugars

Technology / Case number: #21846
Alison Wendlandt / Yong Wang / Hayden Carder
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Functionalization of MiniHA with Lauric Acid

Technology / Case number: #20135
Bradley Olsen / Allie Obermeyer / Sieun Kim / Lavinia Popescu / Yun Jung Yang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Thermogelling Nanoemulsions for Pharmaceutical Manufacturing

Technology / Case number: #22768
Patrick Doyle / Liang-Hsun Chen
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Improved Treatment for Organ Regeneration and Blocking Scar Formation

Technology / Case number: #25302
Ioannis Yannas
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Gastric-Resident Devices for Gram-level Drug Delivery

Technology / Case number: #20379JQ
Carlo Giovanni Traverso / Andrew Bellinger / Tyler Grant / Malvika Verma / Taylor Bensel / Daniel Minahan / Robert Langer
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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PROTAC Derivatives with Functional Handles for Chemical Conjugation/Modification

Technology / Case number: #20788J
Jeremiah Johnson / Yivan Jiang / Hung Nguyen / Alexandre Detappe / Irene Ghobrial / Michael Agius / Aiden Wang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Use of Choline Supplementation as Therapy for APOE4-Related Disorders

Technology / Case number: #20957WPJ
Li-Huei Tsai / Yuan-Ta Lin / Julia Bonner / Priyanka Narayan / Greg Sienski
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Uses of Amphiphiles in Immune Cell Therapy and Compositions Therefore

Technology / Case number: #21411H
Peter DeMuth / Darrell Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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