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Intracellular Molecular Recording and Memory via Protein Self-Assembly

Technology / Case number: #23746HPM
Edward Boyden / Changyang Linghu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Autocatalytic Base Editing for RNA-Responsive Translational Control

Technology / Case number: #24552YJ
James Collins / Raphael Gayet / Katherine Ilia / Shiva Razavi / Nathaniel Tippens / Kehan Zhang / Xiaoyu Chen / Jonathan Chen / Makoto Lalwani
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Temporally Multiplexed Imaging Technology

Technology / Case number: #24554MH
Edward Boyden / Yong Qian
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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An Endoribonuclease-based Incoherent Feedforward Loop for Accurate Control of Gene Expression Levels in Mammalian Cells

Technology / Case number: #21843
Ron Weiss / Ross Jones / Breanna DiAndreth / Domitilla Del Vecchio / Yili Qian
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Expansion Microscopy

Technology / Case number: #22339
Laurie Boyer / Edward Boyden / Pema Maretich / Alexander Auld / John Day / Catherine Della Santina
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Endogenous Gene Sensing and Actuation by Placement of Non-Coding RNA after Transcriptional Termination Signals

Technology / Case number: #21520
James Collins / Ron Weiss / Jeremy Gam / Elvira Vitu / Casper Enghuus
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Characterization and Utilization of a Subgenomic Promoter Mutant Library for Tuning Expression of Multiple Transgenes from Alphavirus Replicons

Technology / Case number: #21309
Ron Weiss / Jin Huh
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Optimization of Circular Single Stranded DNA using M13 Phage

Technology / Case number: #21211
Christopher Voigt / Uyanga Tsedev / Tae-Gon Cha / Angela Belcher
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Novel Chimeric Antigen Receptor Signaling Domains Derived via Activity-based Directed Evolution

Technology / Case number: #21116
Michael Birnbaum / Taeyoon Kyung
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Redox-Electrodes for Electrochemically-Controlled Bio-Macromolecule Interaction: Bio-Separations, Heterogeneous Enzyme Immobilization, Protein Purification and Sensing, Among Others

Technology / Case number: #18540
Trevor Hatton / Xiao Su
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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TRAV-005 (Needles) 62/795,857

Technology / Case number: #22144J
Selim Olcum / Robert Kimmerling / David Weinstock / Scott Manalis
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Rapid Droplet-Based Systems for Antibody Drug Discovery

Technology / Case number: #23890J
Brandon DeKosky / Matias Gutierrez Gonzalez / Cheng-yu Chung / Ahmed Fahad / Nicoleen Boyle / Shuyan Jin
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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High-throughput Electroporation Device

Technology / Case number: #21871
Cullen Buie / Po-Hsun Huang / Sijie Chen
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Single Cell Super-Resolution Proteomics

Technology / Case number: #24088
Mark Harnett / Dimitra Vardalaki
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living, Uncharted Frontiers
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Programmable RNA Writing with the Novel RNA-Guided RNA-Targeting CRISPR-Cas7-11 Enzyme

Technology / Case number: #24072
Omar Abudayyeh / Jonathan Gootenberg / Wenyuan Zhou / Cian Schmitt-Ulms / Alisan Kayabolen
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure and Engineering of the Type III-E CRISPR-Cas7-11 Effector Complex

Technology / Case number: #23945J
Omar Abudayyeh / Jonathan Gootenberg / Wenyuan Zhou / Hiroshi Nishimasu / Kazuki Kato / Cian Schmitt-Ulms
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Advanced Molecular Recorders

Technology / Case number: #19176
Timothy Lu / Fahim Farzadfard
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Linking Immune Receptor Sequence to Single Cell Transcriptome at Scale

Technology / Case number: #19205
John Love / Todd Gierahn / Ang Tu
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Microfluidic Device for the 3D and Compartmentalized Coculture of Neuronal and Muscle Cells, with Functional Force Readout

Technology / Case number: #18042
Roger Kamm / Sebastien Uzel
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Micro Physiological Model for ALS

Technology / Case number: #20857
Roger Kamm / Sebastien Uzel / Tatsuya Osaki
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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