Endogenous Gene Sensing and Actuation by Placement of Non-Coding RNA after Transcriptional Termination Signals
Invention type: Technology
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Case number: #21520
The present disclosure is related to an engineered nucleic acid encoding a post-poly A signal RNA 3' to a terminator for expression of protein, and/or non-coding RNA. Also provided herein are methods for reducing epigenetic silencing, genetic modification, transcriptional regulation of the engineered nucleic acid described herein.
Researchers
James Collins
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Casper Enghuus
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Elvira Vitu
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Jeremy Gam
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Ron Weiss
Departments: Department of Biological Engineering
Technology Areas: Biotechnology: DNA & RNA Editing, Synthetic Biology / Drug Discovery and Research Tools: Genomics & Proteomics
Impact Areas: Healthy Living
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engineered post-poly a signal rna and uses thereof
United States of America | Granted | 12,203,069
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