High-Throughput Expansion Microscopy

Aspects of the present disclosure are directed to a device configured to be inserted into a well plate. The device may include a main body having a top side and a bottom side, and a plurality of posts extending downwardly from the bottom side of the main body, where the plurality of posts is sized to be inserted into a well plate. The device may further include a plurality of post passageways extending through the plurality of posts. The plurality of posts each have a terminus end opposite the main body, where the terminus ends of the plurality of posts further include a plurality of tapered tips. The present disclosure is also directed to methods of processing a plurality of samples in a well plate using the above-described device.