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Cellular Backpacks for Drug Delivery Across the Blood-Brain Barrier

Technology / Case number: #18547J
Robert Cohen / Natalya Klyachko / Yuling Zhao / Matthew Haney / Elena Batrakova / Roberta Polak / Michael F Rubner
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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In-Pipe Leak Detection System

Technology, Tangible Property / Case number: #19034JC
Kamal Youcef-Toumi / Michael Finn-Henry / Kris Kim / You Wu / Rached Ben-Mansour
Technology Areas: Agriculture & Food / Environmental Engineering / Sensing & Imaging
Impact Areas: Sustainable Future
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Enhancement of Lignocellulosic Fermentation in S. Cerevisiae by Combined Genetic Modulations and Media Supplementation

Technology / Case number: #21982WJ
Gerald Fink / Felix Lam / Gregory Stephanopoulos
Technology Areas: Biotechnology / Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Sustainable Future
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Oleogel Drug Delivery Systems for Pediatric Applications

Technology / Case number: #22116J
Robert Langer / Christina Karavasili / Aniket Wahane / Ameya Kirtane / Giovanni Traverso
Technology Areas: Agriculture & Food / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Analysis and Design of a Membrane-based Triggering Mechanism for Ingestible Devices

Technology / Case number: #22043
Giovanni Traverso / Torben Sebastia Last / Graham Arrick
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living, Advanced Materials
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Manually Actuated Device Capable of On-demand/Programmed Pulsatile Drug Delivery

Technology / Case number: #21833JQ
Giovanni Traverso / Qianqian Wan / Adam Wentworth / SeungHo Lee / Rebecca McManus / Jason Li
Technology Areas: Biotechnology
Impact Areas: Healthy Living
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Multi-stable Device Configurations and Controls for Gastric Drug Delivery Devices

Technology / Case number: #22017J
Robert Langer / Ludwig Erik Aguilar / Jens Laursen / Kuldeep Sanger / Nikolaj Eusebius Jakobsen / Adam Jun Bohr / Torben Sebastia Last / Yi Lu / Graham Arrick / Declan Gwynne / Jesper Windum / Brian Mouridsen / Jacob Wainer / Morten Frederiksen / Niclas Roxhed / Giovanni Traverso
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Flexible Electronics for Analyte Detection

Technology / Case number: #21994JQ
Robert Langer / Luca Di Tizio / Sean You / Hen Wei Huang / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Flower-Inspired System with Shape-Memory Torsion Springs

Technology / Case number: #20940J
Robert Langer / Simo Pajovic / Sahab Babaee / Ester Caffarel Salvador / Giovanni Traverso
Technology Areas: Biotechnology
Impact Areas: Healthy Living
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Biodegradable Polymers for Messenger RNA Delivery to the Lung

Technology / Case number: #19314
Daniel Anderson / Asha Patel / James Kaczmarek / Kevin Kauffman
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure-Guided Chemical Modification of Guide RNA and its Applications

Technology / Case number: #19175V
Robert Langer / Hao Yin / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Derivation of Enteroendocrine Cells and Insulin Expressing Cells

Technology / Case number: #18445J
Robert Langer / Xiaolei Yin / Jeffrey Michael Karp
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Implantable Devices and Methods for Evaluation of Active Agents

Technology / Case number: #17867J
No Inventor / John Santini / Oliver Jonas / Jason Fuller / Robert Tepper
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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sgRNA Chemical Modification for Efficient Gene Editing

Technology / Case number: #17805V
Robert Langer / Hao Yin / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Fully Implantable, Autonomous Closed-Loop System Capable of Long-Term Vital Signs Monitoring and Performing Lifesaving Treatment

Technology / Case number: #23387J
Anantha Chandrakasan / Ian Ballinger / Tom Kerssemakers / Peter Chai / Saurav Maji / SeungHo Lee / Hen Wei Huang / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Computer Science / Energy & Distribution
Impact Areas: Healthy Living, Advanced Materials
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A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Chia-fu Chang / Christina Woo / Sebastian Pomplun / Catherine Henry / Jasmin Kruell / Brice Curtin
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Small Molecule Inhibitors of Interleukin-4

Technology / Case number: #22186J
Angela Koehler / Sean Quinnell / Daniel Sheehy / Luke Ceo / Kelly Tan / Stephen Nestor / Becky Leifer / Shelby Doyle / Arturo Vegas
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Tough Hydrogel Pills Inflating 100 Times in Volume Within 10 Min

Technology / Case number: #20059
Xuanhe Zhao / Xinyue Liu / German Parada Hernandez / Hyunwoo Yuk / Shaoting Lin
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Gastric Residence Electronics

Technology / Case number: #20092J
Robert Langer / Yong Lin Kong / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Communication Systems
Impact Areas: Healthy Living
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Chimeric Degraders of Cyclin Dependent Kinase 9 with Potential Use for Cancer Therapy

Technology / Case number: #22028
Angela Koehler / Mohammed Toure / Florian Kabinger / Julie Urgiles / Andre Richters
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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