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Method for High Efficiency in Vivo Gene Editing

Technology / Case number: #17117H
Tyler Jacks / Hao Yin / Joseph Dorkin / Wen Xue / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Gas Sensors Based Upon Metal Macrocycle-Carbon Composites

Technology / Case number: #16884
Timothy Manning Swager / Graham Sazama / Sophie Liu / Alexander Petty / Jan Schnorr
Technology Areas: Agriculture & Food / Energy & Distribution / Sensing & Imaging
Impact Areas: Sustainable Future
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Method for Modulating the Immune System Using Adjuvant-Loaded Nanoparticle-Bacteria Constructs

Technology / Case number: #16067J
Robert Langer / Georg Stary / Ulrich Von Andrian / Pamela Basto / Aleksandar Radovic-Moreno / Michael Starnbach / Omid Farokhzad
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Nanoparticle Delivery of Adjuvant-Method of Preparation and Uses Thereof

Technology / Case number: #13344J
Robert Langer / Elena Tonti / Jinjun Shi / Matteo Iannacone / Elliot Moseman / Ulrich Von Andrian / Pamela Basto / Frank Alexis / Omid Farokhzad
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Thiol-yne Mediated Synthesis of Multi-Tailed Lipids for siRNA Delivery

Technology / Case number: #15846
Robert Langer / Akinleye Alabi / Kevin Love / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Injectable Hydrogel and Uses Thereof

Technology / Case number: #16662J
Robert Langer / Eric Appel / Weiheng Wang / Omid Veiseh / Matthew Webber / Kun Xue / Benjamin Tang / Yizhou Dong / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Reversible Covalent Modification for Improving Protein Delivery

Technology / Case number: #16581HQ
Darrell J Irvine / Li Tang
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Self-Assembled (Poly-(L-Glutamic Acid-PEG-Drug)-PLGA Micelles for Multistage Nanoparticle Delivery System

Technology / Case number: #14877J
Moungi G Bawendi / Dai Fukumura / Cliff Wong / Rakesh K. Jain
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Tissue Specific Delivery of Interfering RNA

Technology / Case number: #13947H
Sangeeta Bhatia / Yin Ren
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Robocap

Technology / Case number: #24836J
Robert Langer / Amro Alshareef / Shriya Sruthi Srinivasan / Giovanni Traverso
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Production of Stable Non-Polyadenylated RNAs

Technology / Case number: #15860
Phillip Sharp / Jeremy Wilusz
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living
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Compact, Portable, Re-Configurable Unit for Making On-Demand Pharmaceutical Tablets

Technology / Case number: #19221
David Brancazio / Gregory Hammersmith / Juan Osorio Caicedo / Mohammad Azad / Allan S. Myerson
Technology Areas: Drug Delivery / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Conformable Ultrasound Face Patch for Cavitation Enhanced Transdermal

Technology / Case number: #24824TE
Canan Dagdeviren
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Ionizable Lipid OF-02 and its Use in mRNA Delivery

Technology / Case number: #17733
Daniel Anderson / Rebecca McClellan / Kevin Kauffman / Owen Fenton / Joseph Dorkin
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Human Microbiome Clostridia-Derived Biosynthetic Enzymes/Pathways for the Biological Production of Natural and Non-Natural Fatty Acylated Compounds

Technology / Case number: #20961
Christopher Voigt / Fang-Yuan Chang
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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In Vitro and in Vivo Delivery of Complex Genetic Circuits up to 33kb Using Engineered HSV-1

Technology / Case number: #20746
Ron Weiss / Ross Jones / Jin Huh / Maria Hottelet Foley
Technology Areas: Diagnostics / Drug Delivery
Impact Areas: Healthy Living
License

Computational Reconfigurable Imaging Spectrometer (CRISP)

Technology / Case number: #19426L
Sumanth Kaushik / Ryan Sullenberger / Adam Milstein / Yaron Rachlin / Charles Wynn
Technology Areas: Agriculture & Food / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living, Sustainable Future
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In-Pipe Leak Detection via Multi-Point Close Proximity Scanning

Technology / Case number: #14570KJ
Kamal Youcef-Toumi / Rached Ben-Mansour / Dimitrios Chatzigeorgiou / Stephen Ho / Sanjay Emani Sarma
Technology Areas: Agriculture & Food / Industrial Engineering & Automation
Impact Areas: Sustainable Future
License

Oligomeric Conjugates for siRNA Delivery and Glucose-Responsive Insulins

Technology / Case number: #15977J
Robert Langer / Rosemary Kanasty / Arturo Vegas / Daniel Anderson
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

Layer-by-Layer Based Nanoparticles for Systemic Delivery Applications

Technology / Case number: #14680
Paula Hammond / Zhiyong Poon
Technology Areas: Chemicals & Materials / Computer Science / Drug Delivery
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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