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A Bioinspired Design of Self-Adjuvanted C3d-Fusion SARS-CoV-2 mRNA Vaccines

Technology / Case number: #23326
Robert Langer / Bowen Li / Allen Jiang / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Device and Method for Imaging Shortwave Infrared Autofluorescence

Technology / Case number: #18527J
Oliver Bruns / Jessica Carr / Klaus Van Leyen / Yi Zheng / Marianne Aellen / Moungi Bawendi
Technology Areas: Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Machine Learning for the Design of Cancer Vaccine Adjuvants

Technology / Case number: #21680J
Carlo Giovanni Traverso / Ameya Kirtane / Daniel Reker / Robert Langer / Lewis Scott Jones / Hyunjoon Kim / Netra Rajesh
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Anti-Zika Virus Antibodies

Technology / Case number: #18525J
Kannan Tharakaraman / Eng Ooi / Kuan Chan / Satoru Watanabe / Subhash Vasudevan / Ram Sasisekharan
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Ionizable Lipids for Messenger RNA Delivery

Technology, Tangible Property / Case number: #24861
Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Hybrid Materials with Living Cells and Tough Hydrogels

Technology / Case number: #18548
Timothy Lu / Xuanhe Zhao / Eleonore Tham / Xinyue Liu / Tzu-Chieh Tang
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Diagnostics / Therapeutics
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Pooled Screening Identifies Genomic Features (Biomarkers) Modulating Nanoparticle-Cell Interactions

Technology / Case number: #22785J
Angela Koehler / Natalie Boehnke / Joelle Straehla / Paula Hammond
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Synthesis of Ester, Carbonate, and Carbamate-derived Novel Biodegradable Ionizable Lipids from Methyl Ricinoleate or Methyl 12-Hydroxystearate and its Applications

Technology / Case number: #23381Q
Luke Rhym / Bowen Li / Akiva Gordon / Manan manan / Jacob Witten / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Enhanced Vaccine Immunogenicity Enabled by Targeted Delivery of Tumor Antigens into Dendritic Cells

Technology / Case number: #25054H
Bradley Pentelute / Cameron Hanna / Emi Lutz / Simon Roessler / Nicholas Truex / Aurelie Rondon / Yehlin Cho / Coralie M. Backlund / Binyou Wang / Darrell Irvine
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Ultrastructural Membrane Expansion Microscopy

Technology / Case number: #25088HM
Edward Boyden / Tay Won Shin
Technology Areas: Chemicals & Materials / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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An App for Quantifying Band Intensities from Diagnostic Lateral Flow Strips

Software / Case number: #22475
James Collins / Miguel Alcantar / Michael Kaminski / Jacqueline Valeri
Technology Areas: Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Optimized Alum-Anchored HIV Env Immunogens

Technology / Case number: #24972HJ
Kristen Rodrigues / Christopher Cottrell / Jon Steichen / William Schief / Darrell Irvine
Technology Areas: Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Near and Shortwave Infrared Polymethine Dyes

Technology / Case number: #19474
Ellen Sletten / Justin Caram / Timothy Swager
Technology Areas: Diagnostics / Electronics & Photonics / Sensing & Imaging
Impact Areas: Healthy Living
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Method for Point-of-use Testing for Bacteriological Water Contamination in Resource-Limited Environments

Technology / Case number: #19080
Rohit Karnik / Emily Hanhauser / Michael Bono / Chintan Vaishnav / Sydney Beasley / Anastasios Hart
Technology Areas: Biotechnology / Diagnostics / Environmental Engineering / Sensing & Imaging
Impact Areas: Healthy Living
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Scalable and Safe Quantum Dot Precursor

Technology / Case number: #20834
Daniel Franke / Matthias Ginterseder / Moungi Bawendi
Technology Areas: Chemicals & Materials / Diagnostics / Electronics & Photonics / Sensing & Imaging
Impact Areas: Healthy Living, Advanced Materials
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Device and Method for Isolation and Detection of Target Cells/Particles from Complex Background Matrices

Technology / Case number: #20847
Rohit Karnik / Emily Hanhauser / Michael Bono / Mary Strawser
Technology Areas: Diagnostics
Impact Areas: Healthy Living
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Near Infrared Fluorescent Biosensors for Steroid Hormones

Technology / Case number: #21434
Michael Strano / Michael Lee / Naveed Bakh / Song Wang
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Extending Fluorescent Assays In Vivo for Biomedical Sensing: Wavelength Modulation Spectroscopy

Technology / Case number: #22003
Michael Strano / Volodymyr Koman / Naveed Bakh
Technology Areas: Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Device and Method for Isolation and Detection of Soluble or Particulate Analytes from Complex Background Matrices

Technology / Case number: #23246
Rohit Karnik / Krithika Ramchander / Emily Hanhauser / Mary Strawser / Chun Man Chow
Technology Areas: Agriculture & Food / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living, Sustainable Future
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Antibody-Free Rapid Detection of SARS-CoV-2 Proteins Using Corona Phase Molecular Recognition (CoPhMoRe)

Technology / Case number: #23605
Michael Strano / Xun Gong / Sooyeon Cho / Xiaojia Jin / Sungyun Yang / Jianqiao Cui
Technology Areas: Chemicals & Materials / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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