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Plk1 inhibitor and Microtubule Poison Dual Payload Antibody Drug Conjugates for the Treatment of Cancer

Technology / Case number: #26136
Michael Yaffe / Jesse C Patterson
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Lipid-Polymer Microparticles (mLPM) For Thermostable, Pulsatile mRNA-LNP Vaccines

Technology / Case number: #26154
Robert Langer / Yuting Huang / Linzixuan Rhoda Zhang / Ana Jaklenec
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Branched Poly(-amino esters) for the Delivery of Nucleic Acids

Technology / Case number: #20333JQ
Robert Langer / Gary Liu / James Byrne / Netra Kamat / Hyunjoon Kim / Daniel Reker / Grace Junyue Zhong / Ameya Kirtane / Yunhua Shi / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Amino Acid, Peptide, Polypeptide-Lipids (APPL) Derivatives and Uses Thereof

Technology / Case number: #14910Q
Robert Langer / Akinleye Alabi / Yunlong Zhang / Yizhou Dong / Yi Chen / Delai Chen / Arturo Vegas / Kevin Love / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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A Mechanical Underwater Soft Adhesion System for Kinetic Biosensing and Intelligent Targeted Drug Delivery

Technology / Case number: #26028J
Giovanni Traverso / Yubin Cai / Troy Ziliang Kang / Ming Zhao / Ameya Kirtane
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Lipid Compositions and Methods

Technology / Case number: #25115J
Daniel Anderson / Dennis Shi / Theresa Raimondo / Sho Toyonaga
Technology Areas: Drug Delivery
Impact Areas: Healthy Living
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Synergisms between Small Molecule Boosters and LNP Formulations Uncovered using High Throughput Screening and Machine Learning

Technology / Case number: #26199J
Giovanni Traverso / Deepak Subramanian / Rajib Dey / Ameya Kirtane
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Amorphous Solid Protein Microparticles via Solvent-Based Dehydration

Technology / Case number: #26228
Patrick Doyle / Talia Zheng
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Lipid-Like Materials for Applications in siRNA Delivery

Technology / Case number: #15420
Robert Langer / Joseph Dorkin / Yunlong Zhang / Arturo Vegas / Kathryn Whitehead / Daniel Anderson
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Programmable Insertion Approaches Via Reverse Transcriptase Recruitment

Technology / Case number: #23685
Omar Abudayyeh / Kaiyi Jiang / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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1,3,5-triazinane-2,4,6-trione (TNT) Derivatives and Uses Thereof

Technology / Case number: #15446
Robert Langer / Hao Yin / Akinleye Alabi / Joseph Dorkin / Ahmed Eltoukhy / Yizhou Dong / Delai Chen / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Compositions and Methods to Deliver RNA to Extracellular Matrix Producing Cells

Technology / Case number: #25390J
Daniel Anderson / Dennis Shi / Theresa Raimondo / Sho Toyonaga
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Mucin-Inspired Glycopolypeptides for Managing Microbial Infections

Technology / Case number: #26189J
Katharina Ribbeck / Jessica Kramer / Michaela Gold / Kelsey Wheeler
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Women's Health
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Self- Regulated Peptide Hydrogel for Closed Loop Insulin Delivery

Technology / Case number: #15056J
Robert Langer / Alex Aimetti / Zhen Gu / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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CD80 is a Biomarker of p53 Activity and a Target for Cancer Therapy

Technology / Case number: #15386H
Tyler Jacks / Leah Schmidt / David Feldser
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Polyamine-Fatty Acid Derived Lipidoids for Drug Delivery

Technology / Case number: #16367
Daniel Anderson / Rebecca McClellan / Owen Fenton / Joseph Dorkin
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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1,2-Aminoalcohol Lipidoids (II)

Technology / Case number: #13661Q
Robert Langer / Kathryn Whitehead / Kevin Love / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Valency Controlled Quantum Dots with Tunable Number of Biotin Binding Sites

Technology / Case number: #12606B
Moungi G Bawendi / Alice Ting
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Electronics & Photonics / Therapeutics
Impact Areas: Healthy Living
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Methods and Compositions for Protein Labeling Using Lipoic Acid Ligases

Technology / Case number: #12773
Alice Ting
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
License

Self-Assembling Peptides Incorporating Modifications and Methods of Use Thereof

Technology / Case number: #13846XE
Technology Areas: Biomaterials & Bioelectronics / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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