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Protein Retrosplicing Enabled by a Double Ligation Reaction

Technology / Case number: #15368
Bradley L. Pentelute / Xiaoli Liao / Amy Rabideau / Jingjing Ling / Rocco Policarpo
Technology Areas: Computer Science / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Identification of Mitochondrial GABA Transporter

Technology / Case number: #26187
Matthew Vander Heiden / Samuel Block
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Fluorescent Metal-Based Nitric Oxide Sensor for Live Cells

Technology / Case number: #11806
Mi Hee Lim / Stephen J Lippard
Technology Areas: Chemicals & Materials / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Self-Assembling Peptides Incorporating Modifications and Methods of Use Thereof

Technology / Case number: #12321XE
Akihiro Horii / Fabrizio Gelain / Xiumei Wang / Shuguang Zhang
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Metakaryocides for Treatment of Cancers and Other Diseases with Metakaryotic Stem Cells

Technology / Case number: #15279
Elena Gostjeva / William Thilly
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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High Throughput Isolation of Antigen-Specific Antibodies and Cells

Technology / Case number: #16927J
Han Wei Hou / Aniruddh Sarkar / Galit Alter / Jongyoon Han
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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One-Step Protein Analysis Using Slanted Nanofilter Array

Technology / Case number: #17391
Sung Ko / Jongyoon Han
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Single Molecule Peptide Sequencing in Polymer Gel

Technology / Case number: #25381HM
Edward Stuart Boyden / Chi Zhang / Camille Mitchell / Hao Wang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Machine-Learning Optimized Proteins and Enzymes

Technology / Case number: #26015J
Omar Abudayyeh / Jonathan S. Gootenberg / Lukas Villiger / Kaiyi Jiang / Matteo Di Bernardo / Zhaoqing Yan
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Diminished Proteolytic Shedding of Receptor Tyrosine Kinases Mediates MEK Inhibitor Resistance in Triple-Negative Breast Cancer

Technology / Case number: #16742
Aaron Meyer / Miles Miller / Madeleine Oudin / Linda Griffith / Douglas Lauffenburger / Frank Gertler
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Women's Health
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Extended Transient Transfection by Repeated Delivery of RNA

Technology / Case number: #13415
Matthew Angel / Mehmet Yanik
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Surface Binding of Nanoparticles-Based Drug Delivery to Tissue

Technology / Case number: #15731
Rohit N Karnik / Cliff Wong / Ambika Bajpayee / Alan Grodzinsky / Moungi G Bawendi
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Nanoparticle Technology for Immune Response Against Small and Macromolecules-Method of Preparation and Uses Thereof

Technology / Case number: #13399J
Frank Alexis / Pamela Basto / Ulrich Von Andrian / Elliot Moseman / Matteo Iannacone / Jinjun Shi / Elena Tonti / Robert Langer / Omid Farokhzad
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Glycan-Receptor Binding of the Novel Influenza A Virus H7N9 Hemagglutinin

Technology / Case number: #16359
Akila Jayaraman / Kannan Tharakaraman / Nathan Stebbins / Rahul Raman / Ram Sasisekharan
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Selective Nitric Oxide Optical Sensors Based on Near Infrared Fluorescent Single Walled Carbon Nanotubes (SWNT)

Technology / Case number: #13445
Michael S. Strano / Jong Ho Kim / Daniel Heller / Jingqing Zhang
Technology Areas: Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Multi-Parameter Data-Set for Detection of Thrombotic Risk

Technology / Case number: #13105J
Elazer R Edelman / Kumaran Kolandaivelu
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
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Brd4 as a Prognostic Indicator and Modulator of the Cell Response to DNA Damage

Technology / Case number: #15011
Scott Floyd / Michael Yaffe
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Inhibition of Histone Deacetylase 2 Facilitates Extinction of Aversive Memory

Technology / Case number: #13759HBJRQ
Li-Huei Tsai / Stephen Haggarty / Jisong Guan / Edward Holsen / Florence Wagner / Johannes Graff
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Programmable Gene Insertion with Paired Targeting Guides

Technology / Case number: #24104
Omar Abudayyeh / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Synergistic Tumor Treatment with Extended-PK IL-2 & Monoclonal Antibodies

Technology / Case number: #15627
Shuning (Annie) Gai / Byron Kwan / Karl Dane Wittrup
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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