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Computationally Engineering Integrase Variants with Improved Activity

Technology / Case number: #25676
Omar Abudayyeh / Jonathan Gootenberg / Kaiyi Jiang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Chromatographic Enrichment Platform for the Discovery of Novel Non-Canonical Cell-Penetrating Peptides for Antisense Oligonucleotide Delivery

Technology / Case number: #25261
Bradley Pentelute / Carly Schissel / Charlotte Farquhar
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Lipids and Formulations for Intramuscular and Systemic Delivery of mRNA

Technology / Case number: #25351J
Arnab Rudra / Akash Gupta / Kaelan Reed / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Methods And Compositions For High-Throughput Compressed Screening For Therapeutics

Technology / Case number: #21936RH
Alexander Shalek / Benjamin Mead / Conner Kummerlowe / No Inventor
Technology Areas: Computer Science / Therapeutics
Impact Areas: Healthy Living
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A Stretchable, Wearable Ultrasound Transducer for Wide-Scale Breast Cancer Data Collection

Technology / Case number: #20934TE
Canan Dagdeviren / Lin Zhang
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
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CRISPR-based Diagnostics for Transplantation Medicine

Technology / Case number: #21752J
James Collins / Leonardo Riella / Michael Kaminski
Technology Areas: Biotechnology / Diagnostics
Impact Areas: Healthy Living
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Micro Magnetic Resonance Relaxometry (MRR) for Rapid and Non-invasive Detection of iPSC Quality and Differentiation

Technology / Case number: #24427DJE
Sing Yian Chew / Daniel Roxby / Zu Yao Tan / Tan Dai Nguyen / Jongyoon Han
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Advanced Materials
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High-throughput Cellulose based Pulldown Assay

Technology / Case number: #23189DEJ
Peter Preiser / Hadley Sikes / Patthara Kongsuphol / Huan Jia / Megan McBee / Say Yong Ng / Hoi Lok Cheng / Sing Mei Lim
Technology Areas: Diagnostics
Impact Areas: Healthy Living
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Corynebacterium Probiotic to Prevent or Treat Cutaneous Staphylococcal Disease

Technology / Case number: #23721J
Tami Lieberman / Victor Neel / Alexandra Poret
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Tri-Functional Hydrophilic Self-Crosslinked Dimethylacrylamide Polymer

Technology / Case number: #18698TEM
Edward Boyden / Linyi Gao / Ruixuan Gao / Nikita Obidin
Technology Areas: Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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TOX Inhibitor and Molecular Glue

Technology / Case number: #25241
Angela Koehler / Bocheng Wu
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Methods for the Treatment of Trinucleotide Repeat Expansion Disorders Associated with FAN1 activity via Targeting of FAN1 Splice Site Inhibitory Sequences

Technology / Case number: #24829
Christopher Ng / David Housman
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Novel Peptides Capable of Altering NK Cell Activity

Technology / Case number: #24321JQ
Michael Birnbaum / Brooke Huisman / Chiara Romagnani / Timo Ruckert
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Bioelectronic Devices to Support Transplanted Cells in Vivo for Encapsulated Cell Therapies

Technology / Case number: #23269J
Suman Bose / Robert Langer / Siddharth Krishnan / Matthew Bochenek / Nima Khatib / Daniel Anderson
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Energy & Distribution / Therapeutics
Impact Areas: Healthy Living
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Apparatus for Forming and Processing Arrangements of Embedded Droplets

Technology / Case number: #21603JDE
Patrick Doyle / Arif Nelson / Saif Khan
Technology Areas: Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Genotype-Directed Local Delivery of Targeted Therapeutics at the Tumor Margin

Technology / Case number: #19863J
Carlo Giovanni Traverso / Ameya Kirtane / Daniel Cahill / Ganesh Shankar / Robert Langer
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Formulated, Biodegradable Polymeric Nanoparticles for Nucleic Acid Delivery to Non-Liver Targets

Technology / Case number: #19802
Kevin Kauffman / James Kaczmarek / Asha Patel / Luke Rhym / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Novel Ionizable Lipids Suitable For Lipid Nanoparticle Delivery of mRNA to Lung and Nasal Epithelium, As Well As Lung Endothelium

Technology / Case number: #23594Q
Luke Rhym / Allen Jiang / Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Single-Cell RNA Sequencing Using Click-Chemistry

Technology / Case number: #20396
Dig Mahat / Phillip Sharp
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Receptor Specific Peptides for Bcl-2 Family Anti-apoptotic Proteins

Technology / Case number: #20337J
Amy Keating / Gevorg Grigoryan / Justin Jenson / Vincent Xue / Jianfu Zhou
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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