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Devices for Needless Drug Delivery in the GI tract

Technology / Case number: #21911QJ
Robert Langer / Adam Jun Bohr / Aghiad Ghazal / Drago Sticker / Cody Cleveland / Torben Sebastia Last / Yi Lu / Graham Arrick / Declan Gwynne / Sean You / Jacob Wainer / Niclas Roxhed / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Supramolecular PEGylation of Protein Therapeutics

Technology / Case number: #18077
Robert Langer / Eric Appel / Matthew Webber / Daniel Anderson
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Engineered Binding Proteins that Specifically Target Bacteria

Technology / Case number: #22368
Hadley Sikes / Yining Hao / Ki-Joo Sung
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Collapsible Library Design to Enable Characterization of Hyperdiverse Peptide Libraries

Technology / Case number: #26377J
Bradley L. Pentelute / Dimuthu Vithanage / Corey Johnson / John Albin / Gha Young Lee / Wayne Vuong
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Precision Administration of Ultra-Loaded Injectable Nanocarriers (PAULINA)

Technology / Case number: #26169J
Giovanni Traverso / Cooper Konz / Yogesh Deshpande / Nabil Shalabi / Will Tritschler / SeungHo Lee / Jason Li
Technology Areas: Drug Delivery
Impact Areas: Healthy Living
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Fanzors are RNA-Guided Nucleases Encoded in Eukaryotic Genomes

Technology / Case number: #24942
Omar Abudayyeh / Kaiyi Jiang / Justin Lim / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Machine Learned Chemical Intuition for the AI Generation of Molecules within Specific Chemical Spaces

Technology / Case number: #26403
Brett McGuire / Zachary Fried
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Oxygen-Generating Scaffolds for Stem Cell Depot Support

Technology / Case number: #24650J
Giovanni Traverso / Young-Geun Park
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Methods, Procedures, and Material Compositions to Formulate Thermally Stable Solid-State Lipid Nanoparticles via Drying at Ambient Conditions

Technology / Case number: #26177
Robert Langer / Amy Lee / Khanh Tran / Jinbi Tian / Mina Konakovic Lukovic / Ana Jaklenec
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Poly(-amino ester) Microparticles for Micronutrient Fortification

Technology / Case number: #22992
Robert Langer / Linzixuan Rhoda Zhang / Ruiqing Xiao / Ana Jaklenec
Technology Areas: Agriculture & Food / Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Compacted Powder Needles for Intramucosal Delivery

Technology / Case number: #21149QJ
Giovanni Traverso / Morten Frederiksen
Technology Areas: Biomaterials & Bioelectronics / Therapeutics
Impact Areas: Healthy Living
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Automated Flow Synthesis of Combinatorial Protein Libraries

Technology / Case number: #26382J
Bradley L. Pentelute / Dimuthu Vithanage / Corey Johnson / John Albin / Gha Young Lee / Wayne Vuong
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Innate Immune Modulating RNA Vaccines

Technology / Case number: #26293H
Darrell J Irvine / B.j. Kim
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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AO mRNA-LNP Stabilization

Technology / Case number: #26266
Robert Langer / Tina Huang / Jooli Han / Linzixuan Rhoda Zhang / Ana Jaklenec
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Prolonged-Release Hydrogel Formulations of Toll-Like Receptor Agonists for Intratumoral Injection to Increase Immunotherapy Response

Technology / Case number: #23215J
Robert Langer / Umar Mahmood / Eric Wehrenberg-Klee / Gabrielle Ndakwah / Jan-Georg Rosenboom / Avik Som / Arijit Basu / Giovanni Traverso
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Plk1 inhibitor and Microtubule Poison Dual Payload Antibody Drug Conjugates for the Treatment of Cancer

Technology / Case number: #26136
Michael Yaffe / Jesse C Patterson
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Lipid-Polymer Microparticles (mLPM) For Thermostable, Pulsatile mRNA-LNP Vaccines

Technology / Case number: #26154
Robert Langer / Yuting Huang / Linzixuan Rhoda Zhang / Ana Jaklenec
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Polymeric Core-Shell Particles for Pulsatile Release of HIV Vaccine

Technology / Case number: #26230
Robert Langer / Stacey Lin / Aki Gurram / Rishi Das / Amy Lee / Behnaz Eshaghi / Maria Kanelli / Ana Jaklenec
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

Branched Poly(-amino esters) for the Delivery of Nucleic Acids

Technology / Case number: #20333JQ
Robert Langer / Gary Liu / James Byrne / Netra Kamat / Hyunjoon Kim / Daniel Reker / Grace Junyue Zhong / Ameya Kirtane / Yunhua Shi / Giovanni Traverso
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Amino Acid, Peptide, Polypeptide-Lipids (APPL) Derivatives and Uses Thereof

Technology / Case number: #14910Q
Robert Langer / Akinleye Alabi / Yunlong Zhang / Yizhou Dong / Yi Chen / Delai Chen / Arturo Vegas / Kevin Love / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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