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Amino Acid, Peptide, Polypeptide-Lipids (APPL) Derivatives and Uses Thereof

Technology / Case number: #14910Q
Kevin Love / Arturo Vegas / Delai Chen / Yi Chen / Yizhou Dong / Yunlong Zhang / Akinleye Alabi / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Patient-Specific Benchtop Beating Heart Simulator for Recreating Left Atrial Biomechanics and Hemodynamics for LAA Closure and HFpEF Intervention Testing

Technology / Case number: #25761
Ellen Roche / Keegan Mendez / Manisha Singh
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Expression Constructs for One-Step Construction of Allogeneic CAR-NK Cells

Technology, Tangible Property / Case number: #26118J
Rizwan Romee / Fuguo Liu / Jianzhu Chen
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Connected World
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Reprogram the Genome of M13 Phage for Vaccination and Immunotherapy Applications

Technology / Case number: #25169
Shengnan Huang / Angela Belcher
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Mechanical Underwater Soft Adhesion System for Kinetic Biosensing and Intelligent Targeted Drug Delivery

Technology / Case number: #26028J
Giovanni Traverso / Ameya Kirtane / Ming Zhao / Troy Ziliang Kang / Yubin Cai
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Method for Quantitative Monitoring of In Vivo Tumor Oxygenation

Technology / Case number: #19207JQ
Michael Cima / Gregory Ekchian / Larissa Lee / Robert Cormack / Ehud Schmidt
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Using a Genetically Modified Human IPS Line to Screen for Drugs that Prevent or Treat Alzheimer's Disease

Technology / Case number: #26292P
Li-Huei Tsai / TaeHyun Kim / Leyla Akay / Matheus Victor / Masayuki Nakano
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Single Fibre Computer Enables Textile Networks and Distributed Inference

Technology / Case number: #26084
Zi Jie Gabriel Loke / Henry Cheung / Nikhil Gupta / Syamantak Payra / Yoel Fink
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials / Electronics & Photonics
Impact Areas: Healthy Living, Connected World
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Method to Release Alcohol Reporters for Profiling Disease Characteristics in Breath

Technology / Case number: #25202H
Melodi Anahtar / Shih-Ting (Christine) Wang / Sangeeta Bhatia
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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Amplitude Spectroscopy of a Solid-State Artificial Atom

Technology / Case number: #13407L
David Berns / Mark Rudner / Sergio Valenzuela / William Oliver / Leonid Levitov / Terry Orlando / Karl Berggren
Technology Areas: Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Synergisms between Small Molecule Boosters and LNP Formulations Uncovered using High Throughput Screening and Machine Learning

Technology / Case number: #26199J
Giovanni Traverso / Ameya Kirtane / Rajib Dey / Deepak Subramanian
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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LNP Automation Screening System

Technology / Case number: #26217
Ana Jaklenec / Robert Langer / Linzixuan Rhoda Zhang / Xin Yang / Zhiling Zheng
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Discovery and Engineering of Novel Integrases for High-Efficiency Gene Integration

Technology / Case number: #23554
Omar Abudayyeh / Jonathan S. Gootenberg / Lukas Villiger / Justin Lim
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Amorphous Solid Protein Microparticles via Solvent-Based Dehydration

Technology / Case number: #26228
Patrick Doyle / Talia Zheng
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Lipid-Like Materials for Applications in siRNA Delivery

Technology / Case number: #15420
Kathryn Whitehead / Arturo Vegas / Yunlong Zhang / Joseph Dorkin / Robert Langer / Daniel Anderson
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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2-Aminoindole-Class Antimalarials

Technology / Case number: #14097BJ
Ralph Mazitschek / Sameer Urgaonkar / Cassandra Celatka / Dyann Wirth / Roger Wiegand / Mary Lynn Baniecki / Joseph Cortese / Edmund Sybertz / Renato Skerlj / Yibin Xiang / Elyse Bourque / Jon Clardy
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Hydrophobic Polycationic Coatings That Inhibit Biofilm Formation on Orthopedic Implants and Support Healing During Infection in Sheep

Technology / Case number: #15031J
Bryan Hsu / Thomas Schaer / Suzanne Stewart / Alexander Klibanov
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials
Impact Areas: Healthy Living
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Programmable Insertion Approaches Via Reverse Transcriptase Recruitment

Technology / Case number: #23685
Omar Abudayyeh / Jonathan S. Gootenberg / Lukas Villiger / Kaiyi Jiang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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1,3,5-triazinane-2,4,6-trione (TNT) Derivatives and Uses Thereof

Technology / Case number: #15446
Delai Chen / Yizhou Dong / Ahmed Eltoukhy / Joseph Dorkin / Akinleye Alabi / Hao Yin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Heterocycle-Modified Quinolines for Fluorescence-Based Protein Kinase Sensing

Technology / Case number: #13876
Elvedin Lukovic / Juan Gonzalez Vera / Barbara Imperiali
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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