Translocation of Non-Natural Chemical Entities Through Anthrax Protective Antigen Pore

Disclosed is a new approach for delivering compounds and drugs to the cytosol of living cells through the use of engineered protein transporters. The engineered protein transporters include a pore and a pore specific delivery protein, wherein a reagent such as a drug is attached to one or more of the engineered protein transporters.

Researchers

Bradley Pentelute / Xiaoli Liao / Amy Rabideau / Jingjing Ling / Gizem Akcay / R. Collier

Departments: Department of Chemistry
Technology Areas: Computer Science: Bioinformatics / Drug Discovery and Research Tools: Genomics & Proteomics / Therapeutics: Nucleic Acids
Impact Areas: Healthy Living

  • translocation of non-natural chemical entities through anthrax protective antigen pore
    United States of America | Granted | 9,498,538
  • translocation of non-natural chemical entities through anthrax protective antigen pore
    Japan | Published application
  • translocation of non-natural chemical entities through anthrax protective antigen pore
    Japan | Pending

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