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Ionizable Lipids for Messenger RNA Delivery

Technology, Tangible Property / Case number: #24861
Daniel Anderson / Idris Raji / Jacob Witten
Technology Areas: Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Chia-fu Chang / Christina Woo / Sebastian Pomplun / Catherine Henry / Jasmin Kruell / Brice Curtin
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Synthesis of Ester, Carbonate, and Carbamate-derived Novel Biodegradable Ionizable Lipids from Methyl Ricinoleate or Methyl 12-Hydroxystearate and its Applications

Technology / Case number: #23381Q
Daniel Anderson / Jacob Witten / rajith manan / Akiva Gordon / Bowen Li / Luke Rhym
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Single-shot 16-fold Expansion Microscopy (16ExM)

Technology / Case number: #24859MH
Edward Stuart Boyden / Harley Yoder / Yixi Liu / Shiwei Wang / Tay Won Shin / Laura L Kiessling
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Clockwise Learning Task

Technology / Case number: #25128M
Ann M. Graybiel / Georgios Papageorgiou
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Engineered Synthetic IRES with Improved and Robust Translation in Circular RNA

Technology / Case number: #25300YJ
James Collins / Nayoung Kim / Yu Li / Makoto Lalwani / Xiaoyu Chen / Kehan Zhang / Shiva Razavi / Katherine Ilia
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Reconstituted Lipoprotein Particles to Rescue Lipid Defects in the Alzheimer's Brain

Technology / Case number: #25445P
Li-Huei Tsai / Rebecca Pinals
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Optimized Alum-Anchored HIV Env Immunogens

Technology / Case number: #24972HJ
Darrell J Irvine / William Schief / Jon Steichen / Christopher Cottrell / Kristen Rodrigues
Technology Areas: Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Biodegradable Lipids and Formulations for Intramuscular, In Vitro, and Ex Vivo Transfection of mRNA

Technology / Case number: #23969J
Daniel Anderson / Kaelan Reed / Akash Gupta / Arnab Rudra
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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A Diagnostic and Treatment Prediction Toolkit for Bipolar Disorder based on Polymorphisms in CPG2 Regulatory Domains

Technology / Case number: #23591P
Elly Nedivi / Baovi Vo
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Fluorescence-based detection of protein aggregation and fiber optic-based benchtop instrument

Technology / Case number: #21556
Michael S. Strano / Freddy Nguyen / Sooyeon Cho / Daniel Salem / Xun Gong / Daichi Kozawa
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Dielectric Films for the Control of Cell Adhesion

Technology / Case number: #23881
Kripa K Varanasi / Sophia Sonnert / Baptiste Blanc / Victor Leon
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
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Intracellular Molecular Recording and Memory via Protein Self-Assembly

Technology / Case number: #23746HPM
Edward Stuart Boyden / Changyang Linghu
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Temporally Multiplexed Imaging Technology

Technology / Case number: #24554MH
Edward Stuart Boyden / Yong Qian
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Analysis, Screening, and Selection for Soluble Protein Function for the Prevention of Infection

Technology / Case number: #25312J
Brandon DeKosky
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Hybrid Hydrogel to Support 3D Culture of Primary Human Cells

Technology / Case number: #25192
Linda Griffith / Samantha Holt
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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  • Women's Health
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Single-Cell Density as A Biomarker for Drug Sensitivity

Technology / Case number: #23741J
Scott Manalis / Kin-Hoe Chow / Sarah Ishamuddin / Teemu Miettinen / Weida Wu / Keith Ligon
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Circular, Strained Zymogen

Technology / Case number: #21110J
Ronald T Raines / Ian Windsor
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Novel Chimeric Antigen Receptor Signaling Domains Derived via Activity-based Directed Evolution

Technology / Case number: #21116
Michael Birnbaum / Taeyoon Kyung
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Optimization of Circular Single Stranded DNA using M13 Phage

Technology / Case number: #21211
Angela Belcher / Tae-Gon Cha / Uyanga Tsedev / Christopher Voigt
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

filtered: 194 results

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