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Systems and Assays for Identifying PU.1 Inhibitors

Technology / Case number: #21734P
Li-Huei Tsai / Alison Mungenast / William Ralvenius
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Carbon Nanoparticles for use as a Vehicle to Target and Treat Macrophages, and Macrophage RNF41 as a Molecule Essential to Switch Macrophage Phenotype

Technology / Case number: #22023
Elazer R Edelman / Pedro Melgar Lesmes
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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TRAV-007 (Genome Sequencing) 62/790,799

Technology / Case number: #22143J
Scott Manalis / Keith Ligon / Mark Stevens / Robert Kimmerling
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Centrifugal Microfluidic Platforms for Cell Pairing and Fusion

Technology / Case number: #22275J
Joel Voldman / Sergio Martinez-Chap / Sergio Martínez-Chapa / MohammadMahdi Aeinhvand
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Mammalian Synthetic Biology Approaches for the Precise Control of mAb N-Glycosylation (Pfizer-MIT PTM Track 2 Interim Joint Summary Document)

Technology / Case number: #19972J
Timothy K Lu / Bruno Figueroa / John Scarcelli / Jeffrey Marshall / Richard Cornell / Giyoung Jung / Michelle Chang / Leonid Gaidukov / Wen Tseng / Nevin Summers / Ron Weiss
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Darrell J Irvine / Yingzhong Li / Ron Weiss
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Circular, Strained Zymogen

Technology / Case number: #21110J
Ronald T Raines / Ian Windsor
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Novel Chimeric Antigen Receptor Signaling Domains Derived via Activity-based Directed Evolution

Technology / Case number: #21116
Michael Birnbaum / Taeyoon Kyung
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Optimization of Circular Single Stranded DNA using M13 Phage

Technology / Case number: #21211
Angela Belcher / Tae-Gon Cha / Uyanga Tsedev / Christopher Voigt
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Characterization and Utilization of a Subgenomic Promoter Mutant Library for Tuning Expression of Multiple Transgenes from Alphavirus Replicons

Technology / Case number: #21309
Ron Weiss / Jin Huh
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Multi-Input miRNA Sensing with Constitutive ERNs to Regulate Multi-Output Gene Expression in Mammalian Cells

Technology / Case number: #23123
Ron Weiss / Lei Wang / Wenlong Xu / Erez Pery / Deepak Mishra
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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M13 Phage based Gene Therapy Platform (Chapter 4 of Thesis Work)

Technology / Case number: #23296
Angela Belcher / Uyanga Tsedev
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Preferential Crystallization of fullrAAVs in a Hanging Drop Crystallizer as an Alternative Method for Downstream Purification of rAAV-based Gene Therapies

Technology / Case number: #24870
Anthony Sinskey / Vivekananda Bal / Moo Sun Hong / Stacy Springs / Richard D Braatz / Paul Barone
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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In Solution Monoclonal Polony Generation on Inorganic Nanoparticle

Technology / Case number: #25039
Ashwin Gopinath / Emily Wu / Nayan Agarwal
Technology Areas: Chemicals & Materials / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
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Multiplexed Expansion Revealing

Technology / Case number: #24562MH
Edward Stuart Boyden / Margaret Schroeder / Jinyoung Kang
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Constriction-Minimizing Microfluidic Devices Enabling Co-Culture in Engineered Hydrogels

Technology / Case number: #24723P
Robert Langer / Alice Stanton / Li-Huei Tsai
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Methods for Machine-Learning Guided Protein Design

Technology / Case number: #25084
Omar Abudayyeh / Matteo Di Bernardo / Kaiyi Jiang / Jonathan S. Gootenberg
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Hybrid Hydrogel to Support 3D Culture of Primary Human Cells

Technology / Case number: #25192
Linda Griffith / Samantha Holt
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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  • Women's Health
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Analysis, Screening, and Selection for Soluble Protein Function for the Prevention of Infection

Technology / Case number: #25312J
Brandon DeKosky
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Molecular Time Capsules Enable Transcriptomic Recording in Living Cells

Technology / Case number: #25337
Gene-Wei Li / Dylan McCormick / Jack Rubien / Mirae Parker
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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