Multi-Input miRNA Sensing with Constitutive ERNs to Regulate Multi-Output Gene Expression in Mammalian Cells

Exclusively Licensed

Provided herein are sequestrons for detecting an miRNA profile indicative of a cell state and expressing an output molecule in cells having such an miRNA profile. Also provided are methods of using sequestrons provided herein.

Researchers

Ron Weiss / Lei Wang / Wenlong Xu / Erez Pery / Deepak Mishra

Departments: Department of Biological Engineering
Technology Areas: Biotechnology: Sensors & Monitoring, Synthetic Biology / Drug Discovery and Research Tools: Cell Interrogation
Impact Areas: Healthy Living

  • multi-input mirna sensing with constitutive erns to regulate multi-output gene expression in mammalian cells
    Japan | Published application
  • multi-input mirna sensing with constitutive erns to regulate multi-output gene expression in mammalian cells
    United States of America | Published application
  • multi-input mirna sensing with constitutive erns to regulate multi-output gene expression in mammalian cells
    European Patent Convention | Published application
  • multi-input mirna sensing with constitutive erns to regulate multi-output gene expression in mammalian cells
    Israel | Pending

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