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A Dynamic Single-Cell Fragility Test that Assesses Red Blood Cell Membrane Integrity with Applications to Stored Blood

Technology / Case number: #25732
Fang Kong / Subra Suresh / Ming Dao
Technology Areas: Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Computationally Engineering Integrase Variants with Improved Activity

Technology / Case number: #25676
Omar Abudayyeh / Jonathan Gootenberg / Kaiyi Jiang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Chromatographic Enrichment Platform for the Discovery of Novel Non-Canonical Cell-Penetrating Peptides for Antisense Oligonucleotide Delivery

Technology / Case number: #25261
Bradley Pentelute / Carly Schissel / Charlotte Farquhar
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Daughterless Male Mammals for Population Suppression

Technology / Case number: #21866TE
Kevin Esvelt
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Sustainable Future
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Long-term Stabilization, Formulation and Tableting of Live Microbial Cells

Technology / Case number: #22886J
Carlo Giovanni Traverso / Robert Langer / Miguel Jimenez / Johanna L'Heureux / Emily Kolaya
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Methods for the Treatment of Trinucleotide Repeat Expansion Disorders Associated with FAN1 activity via Targeting of FAN1 Splice Site Inhibitory Sequences

Technology / Case number: #24829
Christopher Ng / David Housman
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Method for Zero Phase-Lag Real-Time Computation of Hilbert Transform and Analytic Signal

Technology / Case number: #18073TEJ
Edward Boyden / Nir Grossman / David Wang
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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Closed-Loop Noninvasive Brain Stimulation with Simultaneous Imaging to Control Cerebrospinal Fluid Flow in Humans

Technology / Case number: #25482
Laura Lewis / Joshua Levitt
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Computer Science / Sensing & Imaging
Impact Areas: Healthy Living
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Methods for Improving Cross-Ancestry Transferability in Predicting Polygenic Phenotypes from Genetic Variation

Technology / Case number: #24858
Manolis Kellis / Yosuke Tanigawa
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Ingestible Electronics Integrated with Flexible Measurement Electrodes for Gastrointestinal Bioelectric Sensing

Technology / Case number: #23241
Carlo Giovanni Traverso / Robert Langer / Siheng You / So-Yoon Yang / Adam Gierlach / George Selsing
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Computer Science
Impact Areas: Healthy Living, Advanced Materials
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RNAI-Based Method of Screening and Characterizing Drug Combinations

Technology / Case number: #19756
Michael Hemann / Justin Pritchard / Douglas Lauffenburger
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Novel Peptides Capable of Altering NK Cell Activity

Technology / Case number: #24321JQ
Michael Birnbaum / Brooke Huisman / Chiara Romagnani / Timo Ruckert
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Bioelectronic Devices to Support Transplanted Cells in Vivo for Encapsulated Cell Therapies

Technology / Case number: #23269J
Suman Bose / Robert Langer / Siddharth Krishnan / Matthew Bochenek / Nima Khatib / Daniel Anderson
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Energy & Distribution / Therapeutics
Impact Areas: Healthy Living
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Multisensory Gamma Stimulation Promotes Glymphatic Clearance of Amyloid

Technology / Case number: #25696PH
Li-Huei Tsai / Edward Boyden / Ping-Chieh Pao / Cheng-Yi Yang / Mitchell Murdock
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Dissolvable Microcarriers for Adherent Cell Culture

Technology / Case number: #22052JDE
Ee Xien Ng / Krystyn Van Vliet
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Advanced Materials
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Methods of Enhancing the Survival of Introduced Genes and Organisms

Technology / Case number: #22105TE
Kevin Esvelt / Sarah Vitak
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Computationally-Optimized ACE2 Peptides for Competitive Interception of SARS-CoV-2

Technology / Case number: #22320XTE
Pranam Chatterjee / Raghava Manvith Ponnapati / Eyal Perry / Joseph Jacobson
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Zero-Crossing-Based Bio Engineered Sensor

Technology / Case number: #23713J
Timothy Lu / Carlo Giovanni Traverso / Phillip Nadeau / Christoph Winfried Johannes Steiger / Rabia Yazicigil Kirby / Maria Eugenia Inda / Adam Wentworth / Jenna Ahn / Qijun Liu / Miguel Jiminez
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Genotype-Directed Local Delivery of Targeted Therapeutics at the Tumor Margin

Technology / Case number: #19863J
Carlo Giovanni Traverso / Ameya Kirtane / Daniel Cahill / Ganesh Shankar / Robert Langer
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Formulated, Biodegradable Polymeric Nanoparticles for Nucleic Acid Delivery to Non-Liver Targets

Technology / Case number: #19802
Kevin Kauffman / James Kaczmarek / Asha Patel / Luke Rhym / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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