Long-term Stabilization, Formulation and Tableting of Live Microbial Cells

Provided herein are compositions comprising Escherichia coli (E. coli), Saccharomyces boulardii (S. boulardii), Lactobacillus plantarum (L. plantarum), and/or Ensifer meliloti (E. meliloti) and a first stabilizing excipient. Also provided herein are methods of delivering E. coli, S. boulardii, L. plantarum, and/or E. meliloti to a subject in need thereof, methods of inducing bacterial growth in a subject or in a cell, tissue, or biological sample, and methods of inhibiting an enteric pathogen in a subject or in a cell, tissue, or biological sample. Further provided herein are methods of treating dysbiosis in a subject in need thereof.

Researchers

Giovanni Traverso / Robert Langer / Miguel Jimenez / Johanna L'Heureux / Emily Kolaya

Departments: Department of Mechanical Engineering, Office of the Institute Professors
Technology Areas: Drug Discovery and Research Tools: Cell Culture, Cell Lines & Organoids
Impact Areas: Healthy Living

  • long-term stabilization, formulation and tableting of live microbial cells
    United States of America | Pending
  • long-term stabilization, formulation and tableting of live microbial cells
    Patent Cooperation Treaty | Pending

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