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Protein Retrosplicing Enabled by a Double Ligation Reaction

Technology / Case number: #15368
Bradley L. Pentelute / Rocco Policarpo / Jingjing Ling / Amy Rabideau / Xiaoli Liao
Technology Areas: Computer Science / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Engineered Probiotics for Urinary Cancer Diagnosis

Technology / Case number: #15881HJ
Sangeeta Bhatia / Jeff Hasty / Arthur Prindle / Tal Danino
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Methods for Treating Polycystic Kidney Disease

Technology / Case number: #16389J
John M Essigmann / Stefan Somlo / Sorin Fedeles / Bogdan I Fedeles / Robert Croy
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Single Wall Carbon Nanotubes as In Vivo Sensors

Technology / Case number: #16531
Michael S. Strano / Nicole Iverson / Thomas McNicholas / Nigel Reuel
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Extended Transient Transfection by Repeated Delivery of RNA

Technology / Case number: #13415
Mehmet Yanik / Matthew Angel
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Surface Binding of Nanoparticles-Based Drug Delivery to Tissue

Technology / Case number: #15731
Alan Grodzinsky / Ambika Bajpayee / Cliff Wong / Rohit N Karnik / Moungi G Bawendi
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Nanoparticle Technology for Immune Response Against Small and Macromolecules-Method of Preparation and Uses Thereof

Technology / Case number: #13399J
Robert Langer / Elena Tonti / Jinjun Shi / Matteo Iannacone / Elliot Moseman / Ulrich Von Andrian / Pamela Basto / Frank Alexis / Omid Farokhzad
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Glycan-Receptor Binding of the Novel Influenza A Virus H7N9 Hemagglutinin

Technology / Case number: #16359
Rahul Raman / Nathan Stebbins / Kannan Tharakaraman / Akila Jayaraman / Ram Sasisekharan
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Engineering Microbes and Metabolic Pathways for the Production of Ethylene Glycol from Xylose, Glucose, Carbohydrates and Renewable Resources

Technology / Case number: #15064
Gregory Stephanopoulos / Jose Avalos / Marjan De Mey / Brian Pereira / Deepak Dugar
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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Brd4 as a Prognostic Indicator and Modulator of the Cell Response to DNA Damage

Technology / Case number: #15011
Michael Yaffe / Scott Floyd
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Programmable Gene Insertion with Paired Targeting Guides

Technology / Case number: #24104
Omar Abudayyeh / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Vaccine Nanotechnology and Uses Thereof

Technology / Case number: #12788J
Robert Langer / Matteo Iannacone / Elliot Moseman / Tobias Junt / Ulrich Von Andrian / Pamela Basto / Liangfang Zhang / Frank Alexis / Omid Farokhzad
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Universal RNA-Binding Protein Based on the Pumilio Domain Architecture

Technology / Case number: #17629TE
Edward Stuart Boyden / Daniel Martin Alarcon / Katarzyna Adamala
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Biomarkers and Therapeutics for Autism Spectrum Disorders

Technology / Case number: #13589P
Mriganka Sur / Damon Page
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Generation of Specialized, High-Value Cells and Tissues from Human Induced Pluripotent Stem Cells by Recapitulating Early Embryogenesis Using Gata Factor-Induced Endoderm

Technology, Tangible Property / Case number: #16205
Ron Weiss / Mohammad Reza Ebrahimkhani / Patrick Guye
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Method for the Characterization and Differentiation of Material Surfaces Using Compound Responses of Mechanically Driven Cells

Technology / Case number: #17585J
Dick Yue / Xiaoying Zhu / Roland Bouffanais
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Method for High Efficiency in Vivo Gene Editing

Technology / Case number: #17117H
Tyler Jacks / Hao Yin / Joseph Dorkin / Wen Xue / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Programmable Drug Delivery Profiles of Tumor-Targeted Bacteria

Technology / Case number: #15818H
Sangeeta Bhatia / Tal Danino
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Cellular Surface Engineering via Multilayered Polymer Nanostructures

Technology / Case number: #12846
Robert Cohen / Albert Swiston / Darrell J Irvine / Michael F Rubner
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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High-Throughput Screening Metabolic Flux Biosensor

Technology / Case number: #16813JW
Gerald Fink / Jose Avalos / Gregory Stephanopoulos
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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