Programmable Drug Delivery Profiles of Tumor-Targeted Bacteria

The present invention relates to composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence that encodes therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.

Researchers

Tal Danino / Sangeeta Bhatia

Departments: Health Sciences and Technology Program
Technology Areas: Biotechnology: DNA & RNA Editing, Synthetic Biology / Therapeutics: Nucleic Acids
Impact Areas: Healthy Living

  • programmable drug delivery profiles of tumor-targeted bacteria
    United States of America | Granted | 9,994,809
  • programmable drug delivery profiles of tumor-targeted bacteria
    United States of America | Granted | 10,731,125

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