Programmable Drug Delivery Profiles of Tumor-Targeted Bacteria
The present invention relates to composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence that encodes therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.
Researchers
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programmable drug delivery profiles of tumor-targeted bacteria
United States of America | Granted | 9,994,809 -
programmable drug delivery profiles of tumor-targeted bacteria
United States of America | Granted | 10,731,125
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