Method for the Characterization and Differentiation of Material Surfaces Using Compound Responses of Mechanically Driven Cells

The invention is related to a device and method for analysing and controlling cell motility. In accordance with an aspect of the present invention, there if provided a microfluidic device for analyzing and controlling the motility of a cell, the device comprising: (a) a first inlet for introducing a cell sample; (b) an outlet for discharging the cell sample; (c) a microfluidic channel in fluid communication with and intermediate the first inlet and outlet; (d) a first pump coupled to the first inlet for pumping the cell sample in the microfluidic channel; and (d) an observation area within a portion of the microfluidic channel for analysing and controlling the motility of the cell, wherein the first pump generates a shear stress in the observation area, the shear stress generates a shearotactical signal for driving movement of the cell.

Researchers

Dick Yue / Roland Bouffanais / Xiaoying Zhu

Departments: Department of Mechanical Engineering
Technology Areas: Biotechnology: Biomedical Devices & Systems / Drug Discovery and Research Tools: Cell Interrogation
Impact Areas: Healthy Living

  • device and method for analysing and controlling cell motility
    United States of America | Granted | 10,705,012
  • device and method for analysing and controlling cell motility
    Singapore | Published application

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