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Altered DNA Repair Pathway Engagement by Engineered CRISPR-Cas9 Nucleases

Technology / Case number: #23588
Robert Langer / Vikash Pal Singh Chauhan / Phillip Sharp
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Single Camera View-Point Shift

Technology / Case number: #26123
Jae S Lim / Julius Tao / Chong Lee
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Sensing & Imaging
Impact Areas: Connected World
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Automated Flow Synthesis of Combinatorial Protein Libraries

Technology / Case number: #26382J
Bradley L. Pentelute / Dimuthu Vithanage / Corey Johnson / John Albin / Gha Young Lee / Wayne Vuong
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Pulsed Seed Laser Selection to Minimize Spectral Broadening in Pulsed Fiber Laser

Technology / Case number: #25457L
John Kim / Luis Ortega / Mike Riley / Kelsey Johnsen
Technology Areas: Communication Systems / Electronics & Photonics / Sensing & Imaging
Impact Areas: Advanced Materials
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Channel Scalable, Coherent Beam Combined Laser Architecture

Technology / Case number: #25507L
Tso Yee Fan / Kan Thach / Luis Ortega / Louis Isabella / Kelsey Johnsen / Yin Wan Tam / John Kim / Niyom Lue
Technology Areas: Electronics & Photonics / Sensing & Imaging
Impact Areas: Connected World, Advanced Materials
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Plk1 inhibitor and Microtubule Poison Dual Payload Antibody Drug Conjugates for the Treatment of Cancer

Technology / Case number: #26136
Michael Yaffe / Jesse C Patterson
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Methods for Microbial Oil Overproduction from Cellulosic Materials

Technology / Case number: #15695
Gregory Stephanopoulos / Mitchell Tai
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Healthy Living, Sustainable Future
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Method to Improve the Image Quality of Positron Emission Tomography When Using Non-Standard Isotopes Based on Triple Coincidences

Technology / Case number: #16135
Shivang Dave / Joaquin Herraiz / Eduardo Lage / Vicente Parot
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Electronics & Photonics / Sensing & Imaging
Impact Areas: Healthy Living
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All-Optical Three-Dimensional Compression of Electron Pulses for Ultrafast Electron Imaging

Technology / Case number: #17343
Steven G Johnson / Byron Freelon / Timm Rohwer / Nuh Gedik / Liang Jie Wong
Technology Areas: Chemicals & Materials / Communication Systems / Sensing & Imaging
Impact Areas: Connected World, Advanced Materials
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Reprogram the Genome of M13 Phage for Vaccination and Immunotherapy Applications

Technology / Case number: #25169
Angela Belcher / Shengnan Huang
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Methods for Improving Statistical Power in Genetic Discovery by Incorporating Quality Control Flags

Technology / Case number: #25839P
Manolis Kellis / Yosuke Tanigawa
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Expression Constructs for One-Step Construction of Allogeneic CAR-NK Cells

Technology, Tangible Property / Case number: #26118J
Jianzhu Chen / Fuguo Liu / Rizwan Romee
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Connected World
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Using a Genetically Modified Human IPS Line to Screen for Drugs that Prevent or Treat Alzheimer's Disease

Technology / Case number: #26292P
Li-Huei Tsai / Masayuki Nakano / Matheus Victor / Leyla Akay / TaeHyun Kim
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Video Magnification in Presence of Large Motions

Technology / Case number: #17890J
William Freeman / Mohamed Hefeeda / Mohamed Elgharib / Fredo Durand (he/him/his)
Technology Areas: Computer Science / Sensing & Imaging
Impact Areas: Connected World
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Oxygenating Reservoir for Culture Media in Microphysiological Systems

Technology / Case number: #25858
Linda Griffith / Matthew Johnson / Sydney Kim / Priyatanu Roy / David L Trumper
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Programmable Addition Via Site-Specific Targeting Elements (PASTE)

Technology / Case number: #22225
Omar Abudayyeh / Jonathan S. Gootenberg
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Discovery and Engineering of Novel Integrases for High-Efficiency Gene Integration

Technology / Case number: #23554
Omar Abudayyeh / Justin Lim / Lukas Villiger / Jonathan S. Gootenberg
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Wafer Scale Optical Characterization of Photonic Integrated Circuits by Thermal Imaging

Technology / Case number: #12682J
Rajeev Ram
Technology Areas: Communication Systems / Electronics & Photonics / Energy & Distribution / Sensing & Imaging
Impact Areas: Connected World
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Multimodal and Network Phenotyping based on Single-Organelle In Situ Multiplexed Imaging

Technology / Case number: #25842
Mark Bathe / Reuven Falkovich
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
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System for Accelerating Parallel Magnetic Resonance Imaging Reconstruction Using Joint Estimation with a Sparse Signal Model

Technology / Case number: #15457J
Vivek Goyal / Leo Grady / Daniel Weller / Lawrence Wald
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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