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A Ribonucleoprotein Approach to Boost the STING Signaling for Cancer Immunotherapy

Technology / Case number: #21216
Paula Hammond / Yanpu He / Jiahe Li
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Multi-Input miRNA Sensing with Constitutive ERNs to Regulate Multi-Output Gene Expression in Mammalian Cells

Exclusively Licensed Technology / Case number: #23123
Ron Weiss / Lei Wang / Wenlong Xu / Erez Pery / Deepak Mishra
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living

Nucleic Acid-Conjugated Polymeric Nanoparticles for Gene Therapy

Exclusively Licensed Technology / Case number: #23628JQ
Natalie Artzi / Alexander M Cryer / Pere Dosta Pons
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living

Adhesive, Injectable Hydrogels for Local Therapy Delivery to Brain Tumors

Exclusively Licensed Technology / Case number: #24170JQ
Natalie Artzi / Dahis Daniel / Michelle Dion
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living

Tool for Spatially Targeted Access and Placement of Hardware or Drugs in Deep or Consolidated Tissues

Technology / Case number: #25071
Robert Langer / Alexander Madinger / Shriya Sruthi Srinivasan
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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A Multi-Pathway Reporter System that Interrogates Repair of DNA Double-Strand Breaks with Applications for Diagnosis and Therapeutic Treatment of Cancer and Neurodegenerative Diseases

Technology / Case number: #25444
Michael Yaffe / Alex Kruswick
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Small Molecules to Improve Myelination in Alzheimer's Disease and APOE4 Carriers

Exclusively Licensed Technology / Case number: #23168P
Li-Huei Tsai / Matheus Victor / Audrey Effenberger / Djuna von Maydell / Leyla Akay / Jose Davila Velderrain / Joel Blanchard / Manolis Kellis
Technology Areas: Therapeutics
Impact Areas: Healthy Living
Labels
  • Alzheimer's Therapeutics

Use of Choline Supplementation as Therapy for APOE4-Related Disorders

Technology / Case number: #20957WPJ
Li-Huei Tsai / Greg Sienski / Priyanka Narayan / Julia Bonner / Yuan-Ta Lin
Technology Areas: Therapeutics
Impact Areas: Healthy Living
Labels
  • Alzheimer's Therapeutics
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Autocatalytic Base Editing for RNA-Responsive Translational Control

Technology / Case number: #24552YJ
James Collins / Makoto Lalwani / Jonathan C. Chen / Xiaoyu Chen / Kehan Zhang / Nathaniel Tippens / Shiva Razavi / Katherine Ilia / Raphael Gayet
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Controlled Lipid Self-Assembly for Scalable Manufacturing of Next-Generation Immune Stimulating Complexes

Technology / Case number: #24582H
Darrell J Irvine / Ivan Pires / Paula Hammond
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Tandem Peptide Approaches for Delivery to Gram-Negative Bacteria

Technology / Case number: #19017H
Sangeeta Bhatia / Leslie Chan / Ester Kwon
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Cleavable Additives Enable On-Demand Degradable Non-Aromatic Polyurethanes

Technology / Case number: #24572
Jeremiah A. Johnson / Yasmeen Alfaraj / Alayna Johnson / Valerie Lensch / Keith Husted
Technology Areas: Chemicals & Materials
Impact Areas: Sustainable Future, Advanced Materials
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Multiplexed Expansion Revealing

Technology / Case number: #24562MH
Edward Stuart Boyden / Margaret Schroeder / Jinyoung Kang
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Temporally Multiplexed Imaging Technology

Technology / Case number: #24554MH
Edward Stuart Boyden / Yong Qian
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Reconfigurable Multistep Chemical Synthesis System

Technology / Case number: #18563
Klavs F. Jensen / Aaron Bedermann / Kosi Aroh / Dale Thomas / Andrea Adamo / Timothy F Jamison
Technology Areas: Chemicals & Materials
Impact Areas: Sustainable Future
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Redox-Electrodes for Electrochemically-Controlled Bio-Macromolecule Interaction: Bio-Separations, Heterogeneous Enzyme Immobilization, Protein Purification and Sensing, Among Others

Technology / Case number: #18540
T. Alan Hatton / Xiao Su
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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Task Specific Ionic Liquids for Electrochemically Mediated Scrubbing of CO2

Exclusively Licensed Technology / Case number: #18537
T. Alan Hatton / Sahag Voskian / Paul Brown
Technology Areas: Environmental Engineering
Impact Areas: Climate Stabilization, Sustainable Future
Labels
  • CO2 Capture

Robust Anti-Icing Polymer Coatings

Technology / Case number: #18517
Robert Cohen / Dayong Chen / Gareth McKinley
Technology Areas: Chemicals & Materials
Impact Areas: Advanced Materials
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Topology Optimization with Microstructures

Technology / Case number: #18489
Bo Zhu / Melina Skouras / Desai Chen / Wojciech Matusik
Technology Areas: Industrial Engineering & Automation
Impact Areas: Sustainable Future
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Aircraft Fuel Efficiency Tunnel Display for Pilots and Dispatchers

Technology / Case number: #19873
R. John Hansman / Clement Li / Luke Jensen
Technology Areas: Computer Science / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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