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Novel Chimeric Antigen Receptor Signaling Domains Derived via Activity-based Directed Evolution

Technology / Case number: #21116
Michael Birnbaum / Taeyoon Kyung
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Rhinometric Sensing and Gas Detection

Technology / Case number: #21117
Ian Hunter / Nickolas Demas
Technology Areas: Sensing & Imaging
Impact Areas: Climate Stabilization
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Arterial Wall Characterization in Optical Coherence Tomography Imaging

Technology / Case number: #21209
Elazer R Edelman / Lambros Anthanasiou / Max Olender
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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Using Anti-Inflammatory Drugs To Enhance The Neuroprotective Effects Of Non-Invasive Gamma Stimulation

Technology / Case number: #23402P
Li-Huei Tsai / Julia Bonner / Vanesa Fernandez Avalos / Chinnakkaruppan Adaikkan
Technology Areas: Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Multiplexed Expansion Revealing

Technology / Case number: #24562MH
Edward Stuart Boyden / Margaret Schroeder / Jinyoung Kang
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Constriction-Minimizing Microfluidic Devices Enabling Co-Culture in Engineered Hydrogels

Technology / Case number: #24723P
Robert Langer / Alice Stanton / Li-Huei Tsai
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Hybrid Hydrogel to Support 3D Culture of Primary Human Cells

Technology / Case number: #25192
Linda Griffith / Samantha Holt
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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  • Women's Health
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Epoxides for Multimodal Detection of Biomolecules by Expansion Microscopy

Technology / Case number: #24137HM
Edward Stuart Boyden / Yi Cui
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
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Tissue-integrating Neural Interfaces

Technology / Case number: #24351
Polina Anikeeva / Anthony Tabet
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Chemicals & Materials / Sensing & Imaging
Impact Areas: Healthy Living, Advanced Materials
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Smooth Flow Control Systems for Embedded Micropumps on Microfluidic Cell Culture Devices

Technology / Case number: #24379
Linda Griffith / Allison Lenhard / David L Trumper
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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A Machine Learning-guided Whole-Organ Optical Imaging Technique for Non-destructive Identification of Early Pre-Cancer Lesions and Harvesting of Viable Cells from the same for Organoid Culture

Technology / Case number: #25480
Angela Belcher / Vivek Rastogi / Neelkanth Manoj Bardhan
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Electronics & Photonics / Sensing & Imaging
Impact Areas: Healthy Living
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Lung-Cancer Specific T Cell Dysfunction

Technology / Case number: #23004
Karl Dane Wittrup / Duncan Morgan / Brendan Horton / Stefani Spranger / J. Christopher Love
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Temporally Multiplexed Imaging Technology

Technology / Case number: #24554MH
Edward Stuart Boyden / Yong Qian
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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High-Throughput Expansion Microscopy

Technology / Case number: #22339
Laurie Boyer / Catherine Della Santina / John Day / Alexander Auld / Pema Maretich / Edward Stuart Boyden
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Multicellular Integrated Brain Tissue for Investigation and Therapeutic Discovery in Neurological Diseases

Technology / Case number: #22618P
Robert Langer / Adele Bubnys / Alice Stanton / Joel Blanchard / Li-Huei Tsai
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Non-Invasive Staging of Liver Steatosis and Fibrosis via Single-Sided Magnetic Resonance Sensors

Technology / Case number: #22685
Michael Cima / Christopher Frangieh / Ashvin Bashyam
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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Perfusable Host Microfluidic Endothelial Networks for Spheroid and Organoid Co-culture and Immune Cell Infiltration Studies

Technology / Case number: #22749
Roger Kamm / Sharon Lee / Huu Tuan Nguyen
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Fenestration Alignment Program

Technology / Case number: #22841J
Ellen Roche / Marc Schermerhorn / Patric Liang / Tom Dillon
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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Non-Invasive Tactile Stimulation for Improving Motor Function

Technology / Case number: #22928P
Li-Huei Tsai / Arit Banerjee / Guojie Xu / Ho-Jun Suk
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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A Fluidic Platform for Perfusable Vascularized Tumor Spheroids and Organoids

Technology / Case number: #22942
Roger Kamm / Shun Zhang / Zhengpeng (Jason) Wan
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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