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Prolonged-Release Hydrogel Formulations of Toll-Like Receptor Agonists for Intratumoral Injection to Increase Immunotherapy Response

Technology / Case number: #23215J
Giovanni Traverso / Robert Langer / Arijit Basu / Avik Som / Jan-Georg Rosenboom / Gabrielle Ndakwah / Eric Wehrenberg-Klee / Umar Mahmood
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Targeted Trans-splicing Using CRISPR-Cas Systems

Technology / Case number: #20505ER
Jacob Borrajo
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Plk1 inhibitor and Microtubule Poison Dual Payload Antibody Drug Conjugates for the Treatment of Cancer

Technology / Case number: #26136
Jesse C Patterson / Michael Yaffe
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Multi-Waveguide Beam Scanners and Scanning Pattern Methods

Technology / Case number: #26324J
Dirk R Englund / Henry Wen / Matthew Zimmermann
Technology Areas: Biotechnology / Electronics & Photonics / Energy & Distribution / Industrial Engineering & Automation
Impact Areas: Sustainable Future, Connected World
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Lipid-Polymer Microparticles (mLPM) For Thermostable, Pulsatile mRNA-LNP Vaccines

Technology / Case number: #26154
Ana Jaklenec / Robert Langer / Linzixuan Rhoda Zhang / Yuting Huang
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Polymeric Core-Shell Particles for Pulsatile Release of HIV Vaccine

Technology / Case number: #26230
Ana Jaklenec / Robert Langer / Maria Kanelli / Behnaz Eshaghi / Amy Lee / Rishi Das / Aki Gurram / Stacey Lin
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Branched Poly(-amino esters) for the Delivery of Nucleic Acids

Technology / Case number: #20333JQ
Giovanni Traverso / Yunhua Shi / Ameya Kirtane / Grace Junyue Zhong / Daniel Reker / Robert Langer / Hyunjoon Kim / Netra Kamat / James Byrne / Gary Liu
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Amino Acid, Peptide, Polypeptide-Lipids (APPL) Derivatives and Uses Thereof

Technology / Case number: #14910Q
Kevin Love / Arturo Vegas / Delai Chen / Yi Chen / Yizhou Dong / Yunlong Zhang / Akinleye Alabi / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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A MEMS Based Encapsulated Hydrophone

Technology / Case number: #26013LJ
Daniel Freeman / Robert White / Jonathan Anderson / Georgios Karamanis / James Vlahakis
Technology Areas: Chemicals & Materials / Electronics & Photonics / Industrial Engineering & Automation / Sensing & Imaging
Impact Areas: Sustainable Future, Connected World
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Volume Contraction and Substrate Fluidization as a Means to Reduce Drag on Bodies Moving Through a Granular Substrate

Technology / Case number: #13498
Anette Hosoi / Amos Winter / Alexander Slocum
Technology Areas: Agriculture & Food / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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Absorbing Films Deposited and Patterned with Soft Lithography

Technology / Case number: #12080
Michael Bradley / Vladimir Bulovic / Jonathan Tischler
Technology Areas: Chemicals & Materials / Electronics & Photonics / Industrial Engineering & Automation
Impact Areas: Advanced Materials
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Hardware Synthesis from Multicycle Rules

Technology / Case number: #13362
Muralidaran Vijayaraghavan / Michal Karczmarek / Arvind Mithal
Technology Areas: Chemicals & Materials / Computer Science / Industrial Engineering & Automation
Impact Areas: Connected World
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M-Blocks: Modular Angular-Momentum Driven Magnetically Connected Robots

Technology / Case number: #16230
Daniela Rus / John Romanishin / Kyle Gilpin
Technology Areas: Industrial Engineering & Automation
Impact Areas: Advanced Materials
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Continuously Variable Topological Manifold for Entrapped Flow Control

Technology / Case number: #26044
Alfonso Perez / Kenan Sehnawi / Nicolas Gomez Gomez / Pablo Arroyo
Technology Areas: Industrial Engineering & Automation
Impact Areas: Connected World
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Hybrid Drive Spherical Control Moment Gyroscope

Technology / Case number: #25144L
Tyler Hamer / Josh Chabot / David L Trumper
Technology Areas: Computer Science / Industrial Engineering & Automation
Impact Areas: Connected World
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Strategy for Installing Hydrophobic Chains Plus Phosphorus Ligands onto MOFs

Technology / Case number: #25160
Mircea Dinca / Valiallah Hosseininasab / Nathan Gin
Technology Areas: Biotechnology / Chemicals & Materials / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Expression Constructs for One-Step Construction of Allogeneic CAR-NK Cells

Technology, Tangible Property / Case number: #26118J
Rizwan Romee / Fuguo Liu / Jianzhu Chen
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Connected World
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Transformer Stand to Sit Robot

Technology / Case number: #25883
Emily Kamienski / Harry Asada
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Healthy Living
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Reprogram the Genome of M13 Phage for Vaccination and Immunotherapy Applications

Technology / Case number: #25169
Shengnan Huang / Angela Belcher
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Bioinspired Soft Enteroscopic Robot for Facilitating Locomotion, Steering, and Intervention in the Deep Small Intestine

Technology / Case number: #26029J
Giovanni Traverso / Mujtaba Jebran / Sahab Babaee / Binbin Ying
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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