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Systems, Methods, And Compositions For RNA-Guided RNA-Targeting CRISPR Effectors from Type III Systems

Technology / Case number: #23239
Omar Abudayyeh / Jonathan Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Small Molecule Binders of the Oncogenic Fusion Transcription Factor PAX3-FOXO1

Technology / Case number: #23850J
Angela Koehler / Shelby Doyle / Becky Leifer / Madeleine Henley / Beat Schaefer / Marco Wachtel
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Metal-Organic Frameworks Mediated Macromolecule Delivery System

Technology / Case number: #22862J
Carlo Giovanni Traverso / Robert Langer / Adam Wentworth / Xiaoyue Qi
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Novel Small Molecule Modulators of Myb-Mediated Transcription with Potential Use for Cancer Therapy

Technology / Case number: #22044
Angela Koehler / Becky Leifer / Florian Kabinger / Brice Curtin / Jasmin Kruell
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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A Platform for Continuous Directed Evolution in Human Cells

Technology / Case number: #19909
Matthew Shoulders / Louis Papa / Christopher Moore / Chet Berman / Samuel Hendel
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Crystal Structures of Human TorsinA and its Dystonia Mutant

Technology / Case number: #18394
Thomas Schwartz / Fatma Esra Demircioglu / Brian Sosa-Alvarado
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Pre-Fever Detection of Infection

Technology / Case number: #18027LJ
Albert Swiston / Tejash Patel / Lauren Milechin / Jack Fleischman / William Pratt / Anna Honko
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Diagnostics
Impact Areas: Healthy Living
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Compositions and Methods to Increase Muscular Strength Without Exercise

Technology / Case number: #19768
Roger Kamm / Vivek Sivathanu
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Method and Apparatus for Imaging Unsectioned Tissue Specimens

Technology / Case number: #18516
Michael Giacomelli / Tadayuki Yoshitake / Lucas Cahill / James Fujimoto
Technology Areas: Diagnostics / Sensing & Imaging / Therapeutics
Impact Areas: Healthy Living
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Potent Agelastatin Derivatives as Modulators for Cancer Invasion and Metastasis

Technology / Case number: #19505J
Mohammad Movassaghi / Rachel Buchsbaum / Alyssa Antropow / Kun Xu
Technology Areas: Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers, Advanced Materials
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Continuous Freeze-Drying of Pharmaceuticals and Biopharmaceuticals in Unit Doses

Technology / Case number: #19494J
Roberto Pisano / Capozzi Carlo / Bernhardt Trout
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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High-Throughput Untranslated Region Engineering and Screening

Technology / Case number: #19123
Timothy Lu / Manolis Kellis / Jicong Cao / Eva Maria Novoa Pardo / Zhizhuo Zhang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Engineered Phagemids for Non-Lytic, Targeted Antibacterial Technologies

Technology / Case number: #18186HJY
James Collins / Russell-John Krom / Prerna Bhargava / Michael Lobritz
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Recombinase-Based Genetic Diversification Schemes

Technology / Case number: #18173
Timothy Lu / Sara Da Luz Areosa Cleto
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Liquid Biopsy Detection of Minimal Residual Disease in Leukemia Using Closed-Loop Microfluidics

Technology / Case number: #18989DE
Kyungyong Choi / Hyunryul Ryu / Bee Khoo / Jongyoon Han
Technology Areas: Diagnostics
Impact Areas: Healthy Living, Uncharted Frontiers
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Novel Peptidic Agents for Targeting Chemoresistant Anti-Apoptotic Mcl-1

Technology / Case number: #18162
Amy Keating / Raheleh Rezaei Araghi
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Method to Treat Amblyopia

Technology / Case number: #18125PH
Mark Bear / Jeffrey Gavornik / Kevin Duffy / Donald Mitchell / Ming-fai Fong / Arnold Heynen
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Method to Distinguish and Analyze White Blood Cells in the Presence of Red Blood Cells

Technology / Case number: #18889
Shivang Dave / Jason Tucker-Schwartz
Technology Areas: Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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High-Frequency Variable Load Inverter Architecture

Technology / Case number: #18879
David Perreault
Technology Areas: Energy & Distribution
Impact Areas: Sustainable Future
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PNA Amphiphile Adjuvant Delivery Vehicles

Technology / Case number: #18878H
Eric Dane / Darrell Irvine
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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