Novel Small Molecule Modulators of Myb-Mediated Transcription with Potential Use for Cancer Therapy

Provided herein are compounds that inhibit the function of MYB. In particular, provided are compounds that can inhibit MYB and/or disrupt the interaction between MYB and a protein associated with MYB, a protein whose dysregulation is implicated in cancer. Also provided are pharmaceutical compositions comprising the compounds, methods of inhibiting MYB function, and methods of treating cancer in a subject by administering a compound or composition described herein.

Researchers

Angela Koehler / Becky Leifer / Florian Kabinger / Brice Curtin / Jasmin Kruell

Departments: Department of Biological Engineering, David H Koch Institute for Integrative Cancer Res
Technology Areas: Biotechnology: Biomanufacturing, Biomedical Devices & Systems / Therapeutics: Small Molecules
Impact Areas: Healthy Living

  • modulators of myb-mediated transcription and uses thereof
    United States of America | Published application

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