Small Molecule Binders of the Oncogenic Fusion Transcription Factor PAX3-FOXO1
Invention type: Technology
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Case number: #23850J
This technology provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety.
Researchers
Departments: Department of Biological Engineering, David H Koch Institute for Integrative Cancer Res
Technology Areas: Biotechnology: Biomanufacturing, Biomedical Devices & Systems / Therapeutics: Small Molecules
Impact Areas: Healthy Living
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small molecule binders of the oncogenic fusion transcription factor pax3-foxo1
United States of America | Granted | 11,964,022
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