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Gastric-Resident Devices for Gram-level Drug Delivery

Technology / Case number: #20379JQ
Carlo Giovanni Traverso / Andrew Bellinger / Tyler Grant / Malvika Verma / Taylor Bensel / Daniel Minahan / Robert Langer
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Novel Chimeric Antigen Receptor Signaling Domains Derived via Activity-based Directed Evolution

Technology / Case number: #21116
Michael Birnbaum / Taeyoon Kyung
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Ribonucleoprotein Approach to Boost the STING Signaling for Cancer Immunotherapy

Technology / Case number: #21216
Jiahe Li / Yanpu He / Paula Hammond
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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MicroRNA-based Logic Gates that Do Not Use Exogenous Proteins

Technology / Case number: #21334
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Synthesis and Anti-cancer Activity of Communesin Alkaloids

Technology / Case number: #21462
Mohammad Movassaghi / Matthew Pompeo / Jaime Cheah
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Synthesis of Potent Epidithiodiketopiperazines Designed for Facile Derivatization

Technology / Case number: #21469
Mohammad Movassaghi / Joshua Payette / Jaime Cheah / Chase Olsson / Tony Scott
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Accurate Genome Editing

Technology / Case number: #21848
Timothy Lu / Shota Nakade
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Carbon Nanoparticles for use as a Vehicle to Target and Treat Macrophages, and Macrophage RNF41 as a Molecule Essential to Switch Macrophage Phenotype

Technology / Case number: #22023
Elazer Edelman / Pedro Melgar Lesmes
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Simultaneous Delivery of Cancer Treatment Programs to Tumor and Immune Cells

Technology / Case number: #22351
Ron Weiss / Jin Huh / Yingzhong Li
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Compositions of Polypeptides for Subunit Vaccines for SARS-CoV-2

Technology / Case number: #22703
John Love / Neil Dalvie / Sergio Rodriguez
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Fusion Capsid Therapy for COVID-19 and Applies to Other Viruses: Universal "Dominant" Antiviral to Prevent Virus Evolution and Future Pandemics (DNA/RNA/Protein)

Technology, Tangible Property / Case number: #22801MH
Edward Boyden / Robert Langer / Alexi Choueiri / Yong Qian / Bowen Li / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Use of Synthetic ETPs in Reversing Cancer Chemoresistance

Technology / Case number: #22888J
Mohammad Movassaghi / Vikas Sukhatme / Mo Motamedi / Junichi Hanai
Technology Areas: Therapeutics
Impact Areas: Healthy Living
License

Novel Peptides to Inhibit Ena/VASP Proteins

Technology / Case number: #22897J
Amy Keating / Theresa Hwang / Meucci IIunga / Sara Parker / Ghassan Mouneimne / Samantha Hill
Technology Areas: Chemicals & Materials / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Lectin Fingerprinting for Mapping Viral Glycosylation and Identifying Neutralizing Antibodies

Technology / Case number: #22955
Laura Kiessling / Michael Wuo / Amanda Dugan
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Small Molecules Suppressors of APOE Gene Expression and Cerebral Vascular Amyloid Pathology

Technology / Case number: #22991P
Li-Huei Tsai / Joel Blanchard
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Lung-Cancer Specific T Cell Dysfunction

Technology / Case number: #23004
John Love / Stefani Spranger / Brendan Horton / Duncan Morgan / Karl Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Identification of Genes and Mutations that Underlie Adaptation of Gut Microbes to Denovo Degradation of Oxalate

Technology / Case number: #23007
Jeff Gore / Avihu Yona
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Compounds, Compositions, and Methods of Macrocyclic Depsipeptide Antibiotics

Technology / Case number: #23104
Mohammad Movassaghi / Bradley Pentelute / Carly Schissel / Kyan D'Angelo
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Heme-binding Small Peptide

Technology / Case number: #23132
Graham Walker / Siva Sankari Iyer Mani Sankaran / Vigneshbabu Musuri Periasamy
Technology Areas: Therapeutics
Impact Areas: Healthy Living
License

Lipid Nanoparticles for Drug Delivery to Microglia in the Brain

Technology / Case number: #23156P
Li-Huei Tsai / Owen Fenton / Joel Blanchard / Robert Langer / Jason Andresen / Julia Bonner / William Ralvenius
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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