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Directed Evolution of Synthetic Gene Cluster

Exclusively Licensed Technology / Case number: #15653
Christopher Voigt / Michael Smanski / Dehua Zhao
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living

Compositions and Methods for Promoting Hemostasis and other Physiological Activities.

Exclusively Licensed Technology / Case number: #12061J
Gerald Schneider / Yu Xiang Liang / David Tay / Kwok-Fai So / Rutledge Ellis-Behnke
Technology Areas: Biomaterials & Bioelectronics / Therapeutics
Impact Areas: Healthy Living

Single-Shot Full-Field Reflection Phase Microscopy

Non-Exclusively Licensed Technology / Case number: #14694J
Michael Feld / Toyohiko Yamauchi / Zahid Yaqoob / Wonshik Choi / Ramachandra Dasari
Technology Areas: Biotechnology / Diagnostics / Sensing & Imaging
Impact Areas: Healthy Living
License

Spatial-Charge-Map (SCM): A High- Throughput Method for Antibody Screening Based on their Viscosity

Non-Exclusively Licensed Technology, Software / Case number: #15981J
Bernhardt Trout / Neeraj Agrawal / Bernhard Helk
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Rational Design of Affinity Improvement of Dengue 4e11 Antibody

Exclusively Licensed Technology / Case number: #15783
Ram Sasisekharan / Kannan Tharakaraman / Luke Robinson
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Anti-Dengue Virus NS1 Protein Monoclonal Antibodies

Non-Exclusively Licensed Technology / Case number: #18262J
Lee Gehrke / Helena de Puig Guixe / Irene Bosch / Jose Gomez-Marquez / Kimberly Hamad-Schifferli
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

An Amphiphilic Mimotope Vaccine to Enhance FDA-Approved Anti-CD19 CAR T Therapy

Exclusively Licensed Technology / Case number: #22096H
Darrell J Irvine / Benjamin Cossette / Leyuan Ma / Naveen Mehta / Karl Dane Wittrup
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living

Micromolded Particles for Cancer Treatment

Exclusively Licensed Technology / Case number: #21543
Robert Langer / Xueguang Lu / Ana Jaklenec
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living

A Miniature, Low Cost Mass Spectrometer

Exclusively Licensed Technology / Case number: #14770
Harold Hemond / Brian Hemond / Ian Hunter
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living

Engineering Genetic Circuit Interactions Within and Between Synthetic Minimal Cells

Non-Exclusively Licensed Technology, Tangible Property / Case number: #18438TE
Edward Stuart Boyden / Daniel Martin Alarcon / Katarzyna Adamala
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Membrane Probes for Expansion Microscopy

Non-Exclusively Licensed Technology / Case number: #21945TEM
Edward Stuart Boyden / Jeong Seuk Kang / Emmanouil Karagiannis
Technology Areas: Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
License

Prediction, Biosynthesis, and Integration as Biosensors of Molecules With Unique Light Absorbance Signatures And Their Subsequent In-Field Remote Detection Using Hyper-Spectral Cameras

Exclusively Licensed Technology / Case number: #23374
Christopher Voigt / Itai Levin / Yonatan Chemla
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living, Connected World

Augmenting In Situ Sequencing with In Vitro Sequencing Information

Non-Exclusively Licensed Technology / Case number: #19919TEYJ
Edward Stuart Boyden / Jonathan Scheiman / Daniel Goodwin / Andrew Payne / Shahar Alon / Evan Daugharthy / Fei Chen / Asmamaw Wassie
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Iterative Expansion Microscopy

Non-Exclusively Licensed Technology / Case number: #17875TE
Edward Stuart Boyden / Paul Tillberg / Fei Chen / Jae-Byum Chang
Technology Areas: Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
License

Enhanced-Affinity Anti-ECM Nanobody-Cytokine Fusions and Their Applications

Exclusively Licensed Technology / Case number: #23602
Richard Hynes / Emi Lutz / Noor Momin / Noor Jailkhani / Karl Dane Wittrup
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Use of Expandable & Deformable Microspheres for Medical Applications

Exclusively Licensed Technology / Case number: #12143J
Elazer R Edelman / Rinaldo Schiffino / Surbhi Mahajan / Garry Figuly / Tarek Shazly / Michael Feldstein
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living

Automated Diagnostic Analysis of Digitized Handwritten Information

Exclusively Licensed Technology, Software / Case number: #11978J
Randall Davis / Dana Penney
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Sensing & Imaging
Impact Areas: Healthy Living, Connected World

Determinants of Human Receptor Specificity of Influenza A Virus H2N2 Hemagglutinin

Exclusively Licensed Technology / Case number: #14302
Rahul Raman / Xiaoying Koh / Karthik Viswanathan / Aarthi Chandrasekaran / Ram Sasisekharan
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living

Microbial Engineering for the Production of Chemical and Pharmaceutical Products from Isoprenoid Pathway

Exclusively Licensed Technology, Tangible Property / Case number: #13905J
Gregory Stephanopoulos / Heng Phon Too / Parayil Ajikumar
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living

Method for Screening Libraries of Enzymes with Improved Catalytic Properties or Altered Substrate Specificity Using Microwells for the Spatial Separation of Cells Producing the Enzymes

Exclusively Licensed Technology / Case number: #12967WJ
Kerry Love / J. Christopher Love
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics / Therapeutics
Impact Areas: Healthy Living

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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