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Nucleic Acid-Conjugated Polymeric Nanoparticles for Gene Therapy

Technology / Case number: #23628J
Natalie Artzi / Pere Dosta Pons / Alexander Cryer
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Adhesive, Injectable Hydrogels for Local Therapy Delivery to Brain Tumors

Technology / Case number: #24170J
Natalie Artzi / Michelle Dion / Dahis Daniel
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Compositions for the Conditional Delivery of Macromolecules and Combination Therapeutics

Technology / Case number: #24492H
Chayanon Ngambenjawong / Edward Tan / Qian Zhong / Sangeeta Bhatia
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Drinkable, Tough Hydrogels for Gastrointestinal Applications

Technology / Case number: #24642J
Carlo Giovanni Traverso / Robert Langer / Gary Liu / Matthew Pickett
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Targeted Layered Lipid Nanoparticles for in Vivo Extrahepatic Gene Delivery

Technology / Case number: #24751
Namita Nabar / Tamara Dacoba / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Tandem Peptide Approaches for Delivery to Gram-Negative Bacteria

Technology / Case number: #19017H
Ester Kwon / Leslie Chan / Sangeeta Bhatia
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Catheter for Intracardiac 3D Bioprinting

Technology / Case number: #22338J
Jennifer Lewis / Sebastien Uzel / Ellen Roche / Keegan Mendez / Connor Verheyen / Victor Damptey / Milen Shishkov / Sophie Wang / Markus Horvath / Brett Bouma
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Control Replication and Transcription of Self-Replicating RNA in Responses to Small Molecule TMP

Technology / Case number: #22331H
Ron Weiss / Yingzhong Li / Jan Lonzaric / Parisa Yousefpour / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Eric Dane / Masanori Okaniwa / Darrell Irvine
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Antibody Mediated Delivery of Antigen to B Cell Follicles for Enhanced Humoral Response

Technology / Case number: #24727H
Aereas Aung / Darrell Irvine
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Multi-Targeted, Tunable, Sustained Delivery of Drugs and Other Payloads to Charged Avascular Tissues

Technology / Case number: #21303
Yamini Krishnan / Alan Grodzinsky
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Targeting Dendritic Cell Lectins with Glycosylated Particles Containing TLR Ligands Facilitates Efficient Immune Responses

Technology / Case number: #24570J
Laura Kiessling / Valerie Lensch / M.G. Finn / Mohammad Murshid Alam / Robert Hincapie
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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RNA-Loaded Lipid Nanoparticle (LNP)

Technology, Tangible Property / Case number: #24973H
Byungji Kim / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Nanoparticle Conjugates of Highly Potent Toxins

Technology / Case number: #19222
Paiman Ghoroghchian / Ruogu Qi
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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DNA Virus Launched RNA Replicon System (VREP) for Prolonged and High Level Expression of Transgenes with High Precision Controls

Technology / Case number: #20866
Ron Weiss / Jacob Becraft / Jin Huh
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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All-Solid State Abiotically Catalyzed Glucose-Powered Micro Fuel-Cell

Technology / Case number: #19796
Jennifer Lilia Marguerite Rupp / Philipp Simons
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Energy & Distribution
Impact Areas: Healthy Living
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Chiral Oligotriazoles with Precise Structures

Technology / Case number: #19866
Jeremiah Johnson / Yivan Jiang / Hung Nguyen / Yoshiki Shibuya
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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Method and Apparatus for Reducing Power Dissipation of Sensing Device Given an Accuracy Constraint

Technology / Case number: #18695
Phillip Stanley Marbell / Martin Rinard
Technology Areas: Biotechnology / Energy & Distribution
Impact Areas: Healthy Living
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Protein Corona Phase Molecular Recognition (CoPhMoRe)

Technology / Case number: #18316
Michael Strano / Gili Bisker Raviv
Technology Areas: Biotechnology / Drug Delivery
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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