Nucleic Acid-Conjugated Polymeric Nanoparticles for Gene Therapy

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A nanoparticle composition including: a first polymer conjugated to a drug by a linker to form a first polymer compound, the first polymer compound having a net negative charge; and a second polymer conjugated to at least one positively charged group to form a second polymer compound, the second polymer compound having a net positive charge, and the first polymer compound and the second polymer compound interacting electrostatically to form a nanoparticle.

Researchers

Natalie Artzi / Alexander M Cryer / Pere Dosta Pons

Departments: Institute for Medical Engineering and Science
Technology Areas: Chemicals & Materials: Catalysis & Synthesis, Nanotechnology & Nanomaterials, Polymers / Drug Delivery: Microparticles & Nanoparticles / Therapeutics: Nucleic Acids
Impact Areas: Healthy Living

  • nucleic acid-conjugated polymeric nanoparticles and methods of use
    European Patent Convention | Published application
  • nucleic acid-conjugated polymeric nanoparticles and methods of use
    United States of America | Published application

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