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Synthesis of Covalent Protein Dimers that can Inhibit MYC-Driven Transcription

Technology / Case number: #23305WJ
Bradley Pentelute / Isaac Klein / Carly Schissel / Sebastian Pomplun / Andrei Ioan Loas / Jacob Rodriguez / Muhammad Jbara / Ann Boija / Susana Hawken / Charles Li / Stephen Buchwald
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living, Uncharted Frontiers
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Targeting Lung Microbiota and its Responding Immune Pathways for Lung Cancer Treatment

Technology / Case number: #20602HRJ
Paul Blainey / Chengcheng Jin / Georgia Lagoudas / Tyler Jacks
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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RNA-Loaded Lipid Nanoparticle (LNP)

Technology, Tangible Property / Case number: #24973H
Byungji Kim / Darrell Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Target for Modulating Body Mass

Technology / Case number: #21326
Nikola Ivica / Yingzhong Li / Ting Dong / Jianzhu Chen
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Programmable RNA Writing with the Novel RNA-Guided RNA-Targeting CRISPR-Cas7-11 Enzyme

Technology / Case number: #24072
Omar Abudayyeh / Jonathan Gootenberg / Wenyuan Zhou / Cian Schmitt-Ulms / Alisan Kayabolen
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Structure and Engineering of the Type III-E CRISPR-Cas7-11 Effector Complex

Technology / Case number: #23945J
Omar Abudayyeh / Jonathan Gootenberg / Wenyuan Zhou / Hiroshi Nishimasu / Kazuki Kato / Cian Schmitt-Ulms
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Nanoparticle Conjugates of Highly Potent Toxins

Technology / Case number: #19222
Paiman Ghoroghchian / Ruogu Qi
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Synthetic Cell/Condition-Specific Promoters and Enhancers

Technology / Case number: #18570
Timothy Lu / Lior Nissim / Ming Ru Wu
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Transcriptional Sensor for Bile Acids in Bacteroides Thetaiotaomicron

Technology / Case number: #18573
Christopher Voigt / Mao Taketani
Technology Areas: Biotechnology / Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Convergent and Biomimetic Enantioselective Total Synthesis of (-)-Communesin F

Technology / Case number: #18676
Mohammad Movassaghi / Stephen Lathrop / Matthew Pompeo / Wen-Tau Chang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Identification and Application of Ketogenic Properties of Intestinal Stem Cell

Technology / Case number: #20090
George Eng / Omer Yilmaz / Chia-Wei Cheng / Fang Wang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Functionalization of Protective Antigen by Chemical Conjugation

Technology / Case number: #20802
Bradley Pentelute / Zeyu Lu
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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DNA Virus Launched RNA Replicon System (VREP) for Prolonged and High Level Expression of Transgenes with High Precision Controls

Technology / Case number: #20866
Ron Weiss / Jacob Becraft / Jin Huh
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Platinum-Anthracycline Derivative Conjugates and Their Therapeutic Applications

Technology / Case number: #20922
Stephen Lippard / Omer Yilmaz / Fang Wang / Jonathan Braverman
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Intraperitoneal Injection of Nanoparticles Results in Near Perfect Localization Within Peritoneal Tumor Deposits

Technology / Case number: #19352
Xiangnan Dang / Paiman Ghoroghchian / Zhimin Tao / Angela Belcher
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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All-Solid State Abiotically Catalyzed Glucose-Powered Micro Fuel-Cell

Technology / Case number: #19796
Jennifer Lilia Marguerite Rupp / Philipp Simons
Technology Areas: Biomaterials & Bioelectronics / Chemicals & Materials / Energy & Distribution
Impact Areas: Healthy Living
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Systems, Methods, And Compositions For RNA-Guided RNA-Targeting CRISPR Effectors from Type III Systems

Technology / Case number: #23239
Omar Abudayyeh / Jonathan Gootenberg
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Method and Apparatus for Reducing Power Dissipation of Sensing Device Given an Accuracy Constraint

Technology / Case number: #18695
Phillip Stanley Marbell / Martin Rinard
Technology Areas: Biotechnology / Energy & Distribution
Impact Areas: Healthy Living
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Small Molecule Binders of the Oncogenic Fusion Transcription Factor PAX3-FOXO1

Technology / Case number: #23850J
Angela Koehler / Shelby Doyle / Becky Leifer / Madeleine Henley / Beat Schaefer / Marco Wachtel
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Metal-Organic Frameworks Mediated Macromolecule Delivery System

Technology / Case number: #22862J
Carlo Giovanni Traverso / Robert Langer / Adam Wentworth / Xiaoyue Qi
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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