Mark Bathe

Professor

Department
Department of Biological Engineering
Technology Areas
Biotechnology: DNA & RNA Editing, Biomedical Devices & Systems, Sensors & Monitoring, Synthetic Biology / Drug Discovery and Research Tools: Genomics & Proteomics, Cell Interrogation / Therapeutics: Small Molecules, Nucleic Acids, Proteins & Antibodies, Vaccines / Chemicals & Materials: Nanotechnology & Nanomaterials, Catalysis & Synthesis / Diagnostics: Imaging Agents / Electronics & Photonics: Photonics, Quantum Technology, Semiconductors / Computer Science: Bioinformatics

Computational and experimental engineering of DNA and other biomolecules to enable advanced imaging, diagnostic, and therapeutic applications in synthetic biology.

Background and Experience

Dr. Bathe is a Professor in the Department of Biological Engineering at MIT, Director of the MIT New Engineering Education Transformation, Member of the Harvard Medical School Initiative for RNA Medicine, and Associate Member of the Broad Institute of MIT & Harvard. He obtained his Doctoral Degree at MIT working in the Departments of Mechanical, Chemical, and Biological Engineering before moving to the University of Munich as an Alexander von Humboldt Fellow to carry out his postdoctoral research in Biological Physics. He returned to MIT in 2009 to join the faculty in the Department of Biological Engineering, where he runs an interdisciplinary research group focused on the targeted delivery of therapeutic nucleic acids and vaccines, phenotypic profiling of neuronal circuits involved in psychiatric disease, and engineering nucleic acid materials for highly parallel molecular computing and massive data storage.

Technologies

Multimodal and Network Phenotyping based on Single-Organelle In Situ Multiplexed Imaging

Technology / Case number: #25842
Mark Bathe / Reuven Falkovich
Technology Areas: Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Extension of a Finite Element Framework for Calculation of DNA Nanostructure Solution Shape, Mechanical, and Optical Properties

Technology / Case number: #16421
Klaus-Jurgen Bathe / Oskar Hallatschek / Etienne Boulais / Reza Sharifi Sedeh / Lun Yang / Keyao Pan / Matthew Adendorff / Do-Nyun Kim / Mark Bathe
Technology Areas: Computer Science
Impact Areas: Healthy Living
License

The Design of DNA-scaffolded Subunit Vaccines for Enhanced Germinal Center Responses in HIV Vaccination

Technology / Case number: #25982H
Darrell J Irvine / Anna Romanov / Grant Knappe / Mark Bathe
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Advanced Materials
License

DNA-Dye Assembly Based Single-Molecule Fluorescence Lifetime Imaging Probes

Technology / Case number: #23780
Mark Bathe / Jiajia Guo / Gabriela Schlau-Cohen / Xiao Wang / Stephanie Hart
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
License

Ultrafast Single-Step High-Density Conjugation of Quantum Dots and Rods with 2D Lattice Templated Array Alignment using DNA Origami

Technology / Case number: #24671
Mark Bathe / Xin Luo / Chi Chen / Rob Macfarlane
Technology Areas: Chemicals & Materials / Electronics & Photonics
Impact Areas: Advanced Materials
License

Programmable Immunostimulation with Structured DNA Nanoparticles

Technology / Case number: #24273H
Darrell J Irvine / Benjamin Read / Eike-Christian Wamhoff / Tyson Moyer / Rebecca Du / Remi Veneziano / Mark Bathe
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

Structured DNA Conjugates

Technology / Case number: #18588
Mark Bathe / Hyungmin Jun / Tyson Shepherd / Remi Veneziano / Sakul Ratanalert
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

Highly Parallel Enzymatic DNA Synthesis Using Electrowetting Droplet Technology

Technology / Case number: #19620
Mark Bathe / Joseph Berleant / James Banal / Tyson Shepherd
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

RNA Scaffolded Wireframe Origami

Technology / Case number: #24153
Mark Bathe / Molly Parsons / Tyson Shepherd
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Structured DNA Nanoparticle Platform for Protein- and Peptide-based Vaccines

Technology / Case number: #20929H
Darrell J Irvine / Benjamin Read / Eike-Christian Wamhoff / Tyson Moyer / Rebecca Du / Remi Veneziano / Mark Bathe
Technology Areas: Chemicals & Materials / Therapeutics
License

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